依托泊苷长循环亚微乳的制备和理化性质研究  

Preparation and physico-chemical properties of etoposide long circulating submicroemulsion

作　　者：李华龙[1] 尹东东[2] 王杏林[2] 

机构地区：[1]天津市药品检验所,天津300070 [2]天津药物研究院释药技术与药代动力学国家重点实验室,天津300193

出　　处：《现代药物与临床》2013年第2期164-169,共6页Drugs & Clinic

基　　金：国家重点基础研究发展计划(973计划)资助项目(2010CB735602;2012CB724002)

摘　　要：目的制备依托泊苷长循环亚微乳,并对其进行理化性质研究。方法在依托泊苷亚微乳处方的基础上,通过考察乳粒表面固有水化层厚度与聚乙二醇2000-二硬脂酰磷脂酰乙醇胺(PEG2000-DSPE)用量的关系,确定PEG2000-DSPE用量,从而确定了依托泊苷长循环亚微乳的处方和制备工艺,并进行了理化性质研究。结果依托泊苷长循环亚微乳的浓度为0.8mg/mL,平均粒径为(185.4±5.7)nm,Zeta电位为(?51.6±0.8)mV,药物包封率为97.52%。结论得到了包封率在95%以上的依托泊苷浓度为0.8mg/mL的依托泊苷长循环亚微乳的处方和制备工艺。Objective To prepare etoposide long circulating submicroemulsion（ELCSE） and to study its physico-chemical properties.Methods Based on the formulation of etoposide submicroemulsion,the quantity of PEG 2000-DSPE was decided by studying the relationship between the fixed aqueous layer thickness（FALT） of emulsion drop surface and the quantity of PEG 2000-DSPE.Then the ELCSE formulation and the preparing technique were decided,and the physico-chemical properties were studied.Results The concentration of etoposide was 0.8 mg/mL.The mean particle size,Zeta potential,and encapsulation efficiency of ELCSE were（185.4 ± 5.7） nm,（？51.6 ± 0.8） mV,and 97.52%,respectively.Conclusion The ELCSE formulation and preparing technique with etoposide concentration of 0.8 mg/mL and encapsulation efficiency over 95% are obtained.

关 键 词：依托泊苷长循环亚微乳 依托泊苷 长循环亚微乳 聚乙二醇2000-二硬脂酰磷脂酰乙醇胺(PEG2000-DSPE) 

分 类 号：R944[医药卫生—药剂学]