奥美拉唑注射液预防脑出血患者合并上消化道出血的疗效观察  

Therapeutic observation of Omeprazole Injection on preventing upper gastrointestinal hemorrhage in patients with cerebral hemorrhage

作　　者：曹永靖[1] 

机构地区：[1]保定市急救中心,河北保定071000

出　　处：《现代药物与临床》2013年第2期203-205,共3页Drugs & Clinic

摘　　要：目的观察奥美拉唑注射液预防脑出血合并上消化道出血的临床疗效。方法脑出血患者37例,随机分为治疗组(17例)和对照组(18例),对照组患者给予常规药物降低颅压,控制脑水肿和血压,维持电解质平衡;应用止血剂、抗生素等对症治疗;治疗组在对照组基础上应用奥美拉唑40mg静推,2次/d,共14d,治疗结束后评价两组并发上消化道出血的发生率以及患者的急性期病死率。结果治疗组和对照组并发上消化道出血的发生率分别为5.88%、33.33%,两组比较有统计学差异(P<0.01),急性期病死率分别为11.76%、44.44%,两组比较有统计学差异(P<0.01)。结论奥美拉唑注射液不仅可以大大降低脑出血并发上消化道出血的发生率,而且可以明显降低患者急性期的死亡率。Objective To observe the clinical effect of Omeprazole Injection（OI） on preventing upper gastrointestinal hemorrhage in patients with cerebral hemorrhage.Methods The patients with cerebral hemorrhage were randomly divided into treatment group（17 cases） and control group（18 cases）.The patients in the control group were administered with conventional drugs to reduce intracranial pressure,control encephaledema and blood pressure,and maintain electrolyte balance.At the same time,patients were administered with hemostatic agents and antibiotics.The patients in the treatment group were injected with OI on the basis of the control group,twice daily,for 14 d.The incidence of upper gastrointestinal hemorrhage and acute mortality was evaluated in the end of the treatment.Results The incidence of upper gastrointestinal hemorrhage both in the treatment and control groups was 5.88% and 33.33%,respectively,with the significant difference（P 0.01）.The acute mortality in two groups was 11.76% and 44.44%,respectively,with the significant difference（P 0.01）.Conclusion OI could not only greatly reduce the incidence of upper gastrointestinal hemorrhage in patients with cerebral hemorrhage,but also could significantly reduce the acute mortality.

关 键 词：奥美拉唑注射液 脑出血 上消化道出血 

分 类 号：R969.4[医药卫生—药理学]