兔急性肠系膜上静脉血栓形成后IFABP及D-dimer的变化和意义  

Changes and Significance of Serum IFABP and D-dimer in Rabbits With Acute Mesenteric Vein Thrombosis

作　　者：杨恒[1] 王攀[2] 杨强[1] 王家胜[1] 许浩[1] 

机构地区：[1]重庆医科大学附属永川医院普外科,重庆永川402160 [2]重庆市急救医疗中心普外科,重庆400016

出　　处：《四川动物》2013年第2期269-271,275,共4页Sichuan Journal of Zoology

摘　　要：目的本实验通过对兔肠系膜上静脉血栓形成后血清肠脂肪酸结合蛋白(IFABP)和D-二聚体(D-dimer)进行检测,探讨其变化及用于早期诊断急性肠系膜上静脉血栓形成的可行性。方法新西兰大白兔64只,随机分成实验组和对照组(假实验)。采用扎闭静脉、损伤血管壁、激活凝血的方法建立模型。分别测定肠脂肪酸结合蛋白、D-二聚体血清学指标变化。结果与对照组比较,实验组兔血清IFABP和D-dimer显著增加(P<0.01)。各指标不同时间段比较:IFABP值成模后30min显著升高达737.5ng/mL±56.2ng/mL,成模后120min达峰值1800.1ng/mL±85.5ng/mL,术后4h仍维持在较高水平1414.1ng/mL±92.3ng/mL(P<0.01);D-dimer呈持续增高(P<0.01)。结论肠脂肪酸结合蛋白联合D-二聚体也许可作为早期辅助诊断急性肠系膜上静脉血栓形成较理想的生物学指标。Objective This experiment discussed the feasibility of using intestine fatty acid binding protein（IFABP） and D-dimer for early diagnosis of acute superior mesenteric vein thrombosis in rabbits.Methods A total number of 64 New Zealand big rabbits were randomly divided into experimental group and control group.The model was established by ligating the vein,blocking blood flow,injuring the vascular wall and activating the coagulation factor.The hematology indicators of intestine fatty acid binding protein（IFABP） and D-dimer were respectively determined.Results Compared with control group,serum IFABP and D-dimer of rabbits in experimental group significantly increased（P0.01）.Indicator comparison in different periods：IFABP increased significantly to 737.5 ng/mL±56.2 ng/mL in 30 minutes after treatment,reached the peak of 1800.1 ng/mL±85.5 ng/mL in 120 minutes,and remained 1414.1 ng/mL±92.3 ng/mL in 4 hours after treatment（P0.01）;D-dimer were continuously increasing（P0.01）.Conclusion IFABP and D-dimer may be an ideal biological indicator for early diagnosis of acute superior mesenteric vein thrombosis.

关 键 词：肠脂肪酸结合蛋白 D-二聚体 肠系膜上静脉 血栓形成 诊断 

分 类 号：R657.2[医药卫生—外科学]