A new 3, 11-cyclotaxane diterpenoid from Taxus media Rehd. cv. Hicksii  

曼地亚红豆杉中一个新3,11-环紫杉烷型二萜(英文)

作　　者：杨蓉[1] 谢可辉[1] 蔡田芝[1] 傅宏征[1] 

机构地区：[1]北京大学医学部天然药物及仿生药物国家重点实验室,北京100191

出　　处：《Journal of Chinese Pharmaceutical Sciences》2013年第1期32-35,共4页中国药学（英文版）

基　　金：National Natural Science Foundation of China(Grant No.30973628)

摘　　要：The aim of current study was to investigate the chemical constituents of the needles of Taxus media. The isolation and purification of components were achieved by a series of chromatography including silica gel, Sephadex LH-20, MCI and reversed- phase HPLC. Their structures were indentified based on 1D, 2D NMR, and mass spectral analysis. Seven taxane diterpenoids were isolated and identified as ll3,2tt,9ct,1013-tetrahydroxy-5ct-cinnamoyloxy-3,11-cyclotaxa-4（20）-en-13-one （1）, 2it, 7[3, 9ct, 1013, 13tt-pentaacetoxytaxa-4（20）, 11-dien-Sct-ol （2）, 2-deacetoxy-5-decinnamoyltaxinine J （3）, taxuspine F （4）, taxuspinanane K （5）, taxchin A （6）, and baccatin IV （7）. Among them, 1 is a new compound and compounds 2, 5, 6 and 7 are isolated from Taxus media for the first time.研究曼地亚红豆杉针叶的化学成分,应用硅胶、SephadexLH-20、MCI和反相HPLC等多种色谱手段进行分离和纯化,通过1D,2DNMR和MS方法确定化合物的结构。分离得到一个新化合物,命名为1β,2α,9α,10β-tetrahydroxy-5α-cinnamoyloxy-3,11-cyclotaxa-4(20)-en-13-one(1)。另外鉴定了6个已知紫杉烷型二萜类化合物,分别为2α,7β,9α,10β,13α-pentaacetoxytaxa-4(20),11-dien-5α-ol(2),2-deacetoxy-5-decinnamoyltaxinineJ(3),taxuspineF(4),taxuspinananeK(5),taxchinA(6),baccatinIV(7),其中化合物2,5,6,7为首次在曼地亚红豆杉中得到。

关 键 词：Taxus media Taxane diterpenoid Chemical constituents Structural identification 

分 类 号：R284[医药卫生—中药学]