Two new furostanol glycosides fromAsparagus cochinchinensis(Lour.) Merr.  

天门冬中的两个新呋甾皂苷aspacochinoside L和aspacochinoside M(英文)

作　　者：简锐[1] 李军 曾克武[1] 李宁[1] 姜勇[1] 屠鹏飞[1] 

机构地区：[1]北京大学医学部药学院天然药物及仿生药物国家重点实验室,北京100191 [2]北京中医药大学中药现代研究中心,北京100029

出　　处：《Journal of Chinese Pharmaceutical Sciences》2013年第2期201-204,共4页中国药学（英文版）

基　　金：supported by National Key Technology R&D Program"New Drug Innovation"of China(Grant No.2012ZX09301002-002-002and2012ZX09304-005)

摘　　要：Two new furostanol glycosides, aspacochinosides L （1） and M （2）, were isolated from the roots of Asparagus cochinchinensis （Lour.） Merr. Their structures were determined by chemical methods and NMR spectral analysis, including extensive 1D and 2D NMR experiments. Compounds 1 and 2 were investigated for their anti-neuroinflammatory activity in LPS-induced BV-2 cells. Compound 2 showed moderate inhibitory effect on NO production in LPS-induced BV-2 microglial cells with IC 50 value of 32.26 μM.从天门冬的根中分离得到两个新呋甾烷型皂苷aspacochinoside L(1)和aspacochinoside M(2),通过化学和波谱学方法确定了化合物1和2的结构。利用脂多糖(LPS)诱导的小胶质细胞(BV-2)炎症模型,测试了化合物的抗炎活性,其中aspacochinoside M的IC50值为32.26μM。

关 键 词：Asparagus cochinchinensis Steroidal saponin Furostanol glycoside Aspacochinoside 

分 类 号：R284[医药卫生—中药学]