PARTICLE-COLLISION AND POROGEN-LEACHING TECHNIQUE TO FABRICATE POLYMERIC POROUS SCAFFOLDS WITH MICROSCALE ROUGHNESS OF INTERIOR SURFACES  

作　　者：Zhen Pan Ze-hua Qu Zheng Zhang Rong Peng Ce Yan 丁建东 

机构地区：[1]State Key Laboratory of Molecular Engineering of Polymers,Department of Macromolecular Science,Laboratory of Advanced Materials,Fudan University

出　　处：《Chinese Journal of Polymer Science》2013年第5期737-747,共11页高分子科学（英文版）

基　　金：financially supported by Chinese Ministry of Science and Technology(973 programs Nos.2009CB930000 and 2011CB606203);NSF of China(Nos.21034002,91127028 and 51273046)

摘　　要：A facile technique is herein reported to fabricate three-dimensional （3D） polymeric porous scaffolds with interior surfaces of a topographic microstructure favorable for cell adhesion. As demonstration, a well-known biodegradable polymer poly（lactide-co-glycolide） （PLGA） was employed as matrix. Under the porogen-leaching strategy, the large and soft porogens of paraffin were modified by colliding with small and hard salt particles, which generated micropits on the surfaces of paraffin spheres. The eventual PLGA scaffolds after leaching the modified porogens had thus interior surfaces of microscale roughness imprinted by those micropits. The microrough scaffolds were confirmed to benefit adhesion of bone marrow stromal cells （BMSCs） of rats and meanwhile not to hamper the proliferation and osteogenic differentiation of the cells. The insight and technique might be helpful for biomaterial designing in tissue engineering and regenerative medicine.A facile technique is herein reported to fabricate three-dimensional （3D） polymeric porous scaffolds with interior surfaces of a topographic microstructure favorable for cell adhesion. As demonstration, a well-known biodegradable polymer poly（lactide-co-glycolide） （PLGA） was employed as matrix. Under the porogen-leaching strategy, the large and soft porogens of paraffin were modified by colliding with small and hard salt particles, which generated micropits on the surfaces of paraffin spheres. The eventual PLGA scaffolds after leaching the modified porogens had thus interior surfaces of microscale roughness imprinted by those micropits. The microrough scaffolds were confirmed to benefit adhesion of bone marrow stromal cells （BMSCs） of rats and meanwhile not to hamper the proliferation and osteogenic differentiation of the cells. The insight and technique might be helpful for biomaterial designing in tissue engineering and regenerative medicine.

关 键 词：Tissue engineering Porous scaffolds Surface topography Cell adhesion Poly（lactide-co-glycolide） （PLGA）. 

分 类 号：O631.3[理学—高分子化学]