初发2型糖尿病患者血清瘦素浓度与颈动脉内膜中层厚度相关性分析  

Association of serum leptin with intima--media thickness of carotid artery in type 2 diabetes pafients

作　　者：揭然[1] 苏珂[1] 

机构地区：[1]桂林医学院附属医院内分泌科,桂林541001

出　　处：《现代仪器与医疗》2012年第A02期50-50,52,共2页Modern Instruments & Medical Treatment

摘　　要：目的：探讨2型糖尿病（T2DM）患者初发阶段血清瘦素变化与颈动脉内膜中层（IMT）之间的关系。方法：对60例确诊为2型糖尿病患者进行分析，选取30名正常者作为对照组协助研究。对患者进行血清瘦素、空腹血糖、糖化血红蛋白（HbAlc）、C肽、血脂、血压、体重指数（BMI）、腰围等指标进行测定。同时进行高分辨率超声扫描对双侧颈动脉IMT进行检测。结果：T2DM患者血清瘦素浓度与颈动脉内膜中层厚度变化存在正相关性。结论：血清瘦素是导致2型糖尿病患者动脉粥样硬化的重要危险因素。Objective To investigate the relationship between serum leptia and carotid intima--media thickness in patients with type 2 diabetes mellitus. Method 60 patients with type 2diabetes mellitus and 30 normal controls were studied. Fasting serum lep- tin, fasting glucosei-tbAlc, C--peptode , lipids , systolic , diastolic blood pressure body mass index and waist circ--umference were measured in all subjects. The intima--media thickness of common carotid artery was measured by high--resolution ultrasound imaging. Results IMT of T2DM was positively correlated with leptin concentration. Conclusion serum leptin concentration is inde- pendently associated with the IMT of carotid artery, which suggest that leptin may be an independent risk factor of atherosclerosis.

关 键 词：血清瘦素 T2DM 颈动脉内膜 

分 类 号：Q75[生物学—分子生物学]