间充质干细胞在创面愈合中的作用  

Role of mesenchymal stem cells in wound healing

作　　者：段红杰[1] 柴家科[1] 

机构地区：[1]解放军总医院第一附属医院烧伤整形科,全军烧伤研究所,北京100048

出　　处：《中华损伤与修复杂志（电子版）》2012年第6期55-58,共4页Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)

基　　金：科技部国家科技支撑计划(2009BAI87B00)

摘　　要：间充质干细胞是干细胞家族的重要成员,因其具有自我复制、多向分化潜能、免疫调控等特点,在创面愈合中具有重要作用。间充质干细胞治疗的方法有全身应用和局部应用。间充质干细胞可显著促进创面愈合,其可能机制包括:分化为创面修复细胞、促进皮肤网状嵴样结构形成、旁分泌、免疫调理、促进内源性干细胞迁移到伤口局部等。Mesenchymal stem cells（ MSCs） are an important member of stem cell family. They play a key role in the process of wound healing for its characteristics of self-replication, multipotential differentiation, immunomodulation, and so on. The method of MSCs treatment is either systemic or topical application. From the existing results, MSCs treatment can accelerate wound healing process obviously. The possible mechanisms include being differentiated to wound repair cells, prompting formation of reticular ridges, paracrine, immunomodulation, attracting endogenous stem cells to migrate to wound, and so on.

关 键 词：间质干细胞 创面愈合 机制 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]