电针对吗啡慢性注射大鼠成瘾记忆的良性调节  

THE REGULATORY ROLE OF ELECTROACUPUNCTURE AT SHENSHU ACUPOINT ON DRUG MEMORY INDUCED BY CHRONIC MORPHINE INJECTION IN RATS

作　　者：刘胜[1] 路镇穗[1] 周文华[2] 杨国栋[2] 赵伟康[1] 

机构地区：[1]上海中医药大学,上海201203 [2]宁波戒毒研究中心,宁波315010

出　　处：《中国药物依赖性杂志》2013年第2期98-101,共4页Chinese Journal of Drug Dependence

基　　金：上海市教委科研创新项目(13YZ047)资助

摘　　要：目的:建立吗啡慢性注射大鼠成瘾记忆动物模型,观察电针对大鼠成瘾记忆的良性调节作用。方法:通过慢性皮下注射吗啡,或水迷宫平台上注射吗啡,伴高频声音线索,建立大鼠吗啡成瘾记忆模型,电针取穴为肾俞穴,频率2 Hz。结果:d12、d16和d20,吗啡组潜伏期和游泳总距离明显延长。多次电针肾俞穴治疗后,潜伏期和游泳总距离缩短,与吗啡组相比,具有显著性差异(P<0.05)。d16和d20吗啡线索组上平台时间和游泳总距离明显缩短,线索电针组延长上平台所需时间和游泳总距离。结论:电针肾俞穴可以改善慢性注射吗啡所受损的正常记忆能力,又能干预吗啡成瘾记忆,表现出双向调节的特点。Objective： To build up the animal model of addiction memory induced by chronic morphine injection in rats, and to observe the modulatory effect of Electroacupuncture （EA） at Shenshu acupoint on addiction memory. Methods： Morphine addiction in rats was established by chronic subcutaneously（sc） injection morphine, or SC morphine on platform, accompanied with high- frequency voice cue. Acupoint selected in present study was Shen Shu. The frequency of stimulation used was 2 Hz. Results ： Morris water maze test was carried out on day 12, 16 and 20 and indicated that the latency of reaching platform and total swimming distance were longer in morphine group than that of saline group, and EA treatment reduced the latency of reaching platform and decreased the total swimming distance （P〈 0.05 ）. The latency of reaching platform and total swimming distance of morphine cue group were shorter than that of saline cue group on 16 and 20 test day. There is a significant difference between cue EA group and morphine cue group. Conclusion：EA at Shenshu acupoint can bidirectionally modulate addiction memory induced by morphine dependence.

关 键 词：电针 双向调节 成瘾记忆 

分 类 号：R595.5[医药卫生—内科学]