消痈溃得康对乙酸致胃溃疡模型大鼠血清GAS及MTL含量的影响  

Effect of Xiaoyong Kuidekang on Expressions of GAS and MTL in Rat Ulcer Model

作　　者：白析玮[1] 曲怡[1] 蒋宁[1] 孙云峰[1] 林庶茹[1] 才丽平[1] 郑洪新[1] 周学文[1] 

机构地区：[1]辽宁中医药大学,沈阳110847

出　　处：《中国实验方剂学杂志》2013年第8期188-190,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技部973计划项目(2006CB504809);国家自然科学基金项目(81173380)

摘　　要：目的:研究中药消痈溃得康对乙酸致胃溃疡模型大鼠血清胃泌素(gastrin,GAS)和胃动素(motilin,MTL)含量的影响,探讨中药消痈溃得康抗胃溃疡的机制。方法:将大鼠随机分为正常组、假手术组、胃溃疡模型组、消痈溃得康治疗组及奥美拉唑治疗组。大鼠胃黏膜局部投与乙酸制备胃溃疡模型,消痈溃得康治疗组和奥美拉唑治疗组于术后第2天开始分别灌胃给药消痈溃得康(4 g·kg-1)和奥美拉唑(1.25 mg·kg-1),假手术组和胃溃疡模型组给予纯水,给药11 d后,取各组大鼠的血清,酶联免疫法(ELISA)检测血清GAS,MTL的含量。结果:胃溃疡模型组大鼠血清GAS(7.39±0.61)μg·L-1,MTL(514.41±94.25)ng·L-1含量明显高于正常组和假手术组(P<0.01);消痈溃得康治疗组大鼠血清GAS(5.35±0.52)μg·L-1,MTL(311.92±79.75)ng·L-1含量较胃溃疡模型组显著降低(P<0.01)。结论:中药消痈溃得康可能是通过降低胃溃疡大鼠血清GAS、MTL含量,从而达到抑制胃酸、保护胃黏膜、促进溃疡愈合的作用。Objective：To study the effect of Xiaoyong Kuidekang on expressions of gastrin（GAS） and motilin（MTL） in rat ulcer model and to explore the mechanism of gastric ulcer treated by Xiaoyong Kuidekang.Method：The rats were randomly divided into 5 groups randomly：normal group,sham group,ulcer model group,Xiaoyong Kuidekang group and Omeprazole group.Acetic acid was applied to a certain part of the gastric mucosa to establish the ulcer model.The Xiaoyong Kuidekang and Omeprazole treatment group had been implemented with drugs since the 2nd day after the operation,the serum was collected on the 11 th day and the content of GAS and MTL were measured by ELISA method.Result：The GAS and MTL content of serum in ulcer model group was higher than that in the control group and the sham group（P0.01）,the GAS and MTL content of serum was lower in the Xiaoyong Kuidekang group and Omeprazole group than those in the ulcer model group（P0.01）.Conclusion：The Xiaoyong Kuidekang may be mediated by decreased the GAS and MTL content of serum,so as to achieve the protection of gastric mucosa and promote ulcer healing effect.

关 键 词：胃溃疡 消痈溃得康 胃泌素 胃动素 

分 类 号：R285.5[医药卫生—中药学]