益肺胶囊联合痰咳净散对COPD稳定期的临床疗效  

Clinical Effects of Yifei Capsule plus Tankejing Powder on Stable-stage Patients with Chronic Obstructive Pulmonary Disease

作　　者：王琴[1] 

机构地区：[1]白求恩国际和平医院,石家庄050081

出　　处：《中国实验方剂学杂志》2013年第8期281-283,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:探讨益肺胶囊联合痰咳净散对慢性阻塞性肺疾病(COPD)稳定期的临床疗效。方法:98例COPD稳定期患者随机分为观察组和对照组各49例。两组均常规采用非药物治疗,并按需给予化痰、解痉平喘等药物治疗。观察组加服益肺胶囊,4粒/次,3次/d,连续服用12周,在痰多、咳嗽较重时以痰咳净散含服,0.2 g/次,3～6次/d。观察肺功能和BODE指数,采用圣乔治呼吸问卷(SGRQ)评价生活质量。结果:观察组第1秒用力呼气容积(FEV1)和FEV1/用力肺活量(FVC)均较治疗前上升明显(P<0.01),且均高于对照组(P<0.05);观察组呼吸症状、活动能力及疾病影响3个维度评分和SGRQ总评分均低于对照组(P<0.05);观察组FEV1,呼吸困难量表(mMRC)及6 min步行距离(6MWD)3个维度评分和BODE指数均低于对照组(P<0.05)。结论:益肺胶囊联合痰咳净散能改善COPD稳定期患者肺功能,改善临床症状及BODE指数,提高患者生活质量。Objective：To observe the clinical effects of Yifei capsule plus Tankejing powder on stable-stage patients with chronic obstructive pulmonary disease（COPD）.Method：Ninety-eight subjects were randomly divided into observation group and control group（n=49 each）.Both groups were adopted the conventional non-drug therapy,and were given drugs used for dissolveing sputum and antispasmodic on demand.The observation group was given Yifei capsule,4 capsules tid,all for 12 days.Tankejing powder（0.2 g each time,3-6 times daily） was given when abundance of phlegm and heavier cough occurred.The lung function,St George＇s respiratory disease questionnaire（SGRQ） and BODE index were measured to evaluated the quality of life.Result：The observation group showed significant improvement compared with the control group in the following indexes：forced expiratory volume in first second（FEV1）,the ratio of FEV1 and forced vital capacity.There was significant difference between the two groups（P0.05）.The scores of SGRQ and the three dimensions of respiratory symptoms,activity and the affects of disease in the observation group were more lower than those in the control group（P0.05）.The scores of the three dimensions of FEV1,modified medical research council scale（mMRC） and 6 min walking distance（6 MWD） and BODE index were more lower than those in the control group（P0.05）.Conclusion：Yifei capsule plus Tankejing powder can significantly improve the lung function,clinical symptoms and BODE index in patients with COPD,and it can significantly improve the quality of life for patients.

关 键 词：慢性阻塞性肺疾病 益肺胶囊 痰咳净散 BODE指数 圣乔治呼吸问卷 

分 类 号：R287[医药卫生—中药学]