肝苏颗粒对慢性乙型肝炎患者IL-21的影响  

Effect of Gansu Granule on Patients with Chronic Hepatitis B

作　　者：莫菁莲[1] 王政[2] 

机构地区：[1]海南省人民医院药学部,海口570311 [2]海南医学院生物技术专业实验室,海口571101

出　　处：《中国实验方剂学杂志》2013年第8期284-286,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:探讨肝苏颗粒对慢性乙型肝炎(CHB)患者白介素21(IL-21)的影响。方法:86例CHB患者随机分为观察组和对照组各43例。对照组采用派罗欣,180μg/次,1次/周,sc。观察组在此基础上加用肝苏颗粒,9 g/次,3次/d,口服。疗程24周。检测血清IL-21水平、乙肝病毒DNA(HBV-DNA)定量及肝功能。结果:治疗后两组HBV-DNA水平均较治疗前明显降低,观察组低于对照组(P<0.05);两组IL-21均较治疗前明显升高,观察组上升水平高于对照组(P<0.01);观察组治疗后门冬氨酸氨基转移酶(AST),丙氨酸转氨酶(ALT),谷酰转肽酶(GGT)及总胆红素(TBil)低于对照组(P<0.05,P<0.01),白蛋白(ALb)高于对照组(P<0.05)。结论:肝苏颗粒能升高CHB患者IL-21水平,具有抗乙肝病毒和保护肝功能的作用。Objective：To investigate the effect of Gansu granule on patients with chronic hepatitis B（CHB）.Method：Eighty-six subjects were randomly divided into observation group and control group（n=43 each）.Pegasys were given to the control group,180 μg each time,1 time each week.Based on the pegasys treatment,Gansu granule was added to the observation group,9 g,tid,all for 24 weeks.Interlukin-21（IL-21） level,hepatitis B virus-DNA（HBV-DNA） and lung function were quantified and measured.Result：The level of HBV-DNA in both groups after the treatment were lower than those before,the observation group were more lower than that in the control group（P0.05）.IL-21 level in both groups after the treatment were higher than before,the level in observation group was higher than that in the control group（P0.01）.Aspartate aminotransferase（AST）,alanine aminotransferase（ALT）,γ-glutamete transpeptidase（GGT） and total bilirubin（Tbil） in the observation group after the treatment were lower than those in the control group（P0.05,P0.01）,and albumin（Alb） of the observation group after the treatment were higher than that in the control group（P0.05）.Conclusion：Gansu granule can elevate IL-21 level for the patients with CHB.Gansu granule has anti-HBV function and could protect liver function.

关 键 词：慢性乙型肝炎 肝苏颗粒 Α-干扰素 白介素-21 

分 类 号：R287[医药卫生—中药学]