肾康注射液辅助治疗早期糖尿病肾病的疗效及对氧化应激的影响  

Effect of Shenkang Injection as an Adjunctive Treatment on Early Diabetic Nephropathy and on Patient's Oxidative Stress

作　　者：王爱媛[1] 房辉[1] 王余[1] 田骆冰[1] 张坤[1] 唐文军[1] 彭鹏[1] 戴立志 杨岳[1] 

机构地区：[1]唐山工人医院内分泌科,河北唐山063000

出　　处：《中国实验方剂学杂志》2013年第8期308-310,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:探讨肾康注射液辅助治疗早期糖尿病肾病(DN)的临床疗效及对患者氧化应激的影响。方法:66例DN患者随机分为观察组和对照组各33例。对照组严格控制饮食,控制血糖、血压于正常水平,依那普利,5 mg/次,口服,1次/d。观察组在对照组治疗基础上加用肾康注射液,100 mL加入5%葡萄糖300 mL,静脉滴注,1次/d。疗程均为4周。观察两组24h尿白蛋白排泄率(UAER),尿β2微球蛋白(β2-MG),尿微量清蛋白与肌酐的比值(ACR);检测氧化应激指标血清丙二醛(MDA)、超氧化物歧化酶(SOD)及总抗氧化能力(T-AOC)。结果:治疗后观察组UAER,β2-MG,ACR均低于对照组(P<0.01);治疗后观察组SOD,T-AOC水平明显升高,且高于对照组(P<0.01),MDA明显下降,且低于对照组(P<0.01);观察组总有效率84.84%优于对照组的63.64%(P<0.05)。结论:肾康注射液能降低早期糖尿病肾病患者UAER,β2-MG及ACR,提高临床疗效,其机制可能与减少氧化应激反应、增强抗氧化应激能力有关。Objective：To observe the effect of Shenkang injection as an adjunctive treatment on early diabetic nephropathy（DN） and on patients＇ oxidative stress.Method：Sixty-six DN patients were randomly divided into observation group and control group（n=33 each）.The patients in control group were received tight control of diet,blood glucose and blood pressure to maintain normal levels.They were orally taken enalaprilat,5 mg daily.The patients in observation group,on the basis of control group,received Shenkang injection 100 mL mixed with 300 mL 5%glucose,iv,gtt,1 time daily.The treatment course of the two groups lasted 4 weeks.Urinary albumin excretion rates（UAER）,β2-microglobulin（β2-MG）,albumin to creatinine ratio（ACR）,oxidative stress indexes malondialdehyde（MDA）,superoxide dismutase（SOD） and total antioxidant capacity in the two groups were observed.Result：After treatment,UAER,β2-MG and ACR in observation group were lower than those in control group（P0.01）;SOD and T-AOC in observation group were significantly increased and higher than those in control group（P0.01）.MDA in observation group was significantly decreased and lower than that in control group（P0.01）.The total effective rate of observation group（84.84%） was higher than that in control group（63.64%） with a significant difference（P0.01）.Conclusion：Shenkang injection can decrease UAER,β2-MG and ACR in patients with early diabetic nephropathy and improve clinical efficacy,the mechanism of which may be associated with reducing oxidative stress and enhancing anti oxidative stress ability.

关 键 词：糖尿病肾病 肾康注射液 氧化应激 

分 类 号：R287[医药卫生—中药学]