氟比洛芬酯与舒芬太尼联合用于肠道肿瘤术后的代谢调理作用分析  

Analysis Flurbiprofen Ester and Sufentanil Joint for Intestinal Tumor Postoperative Metabolic Toning Effect

作　　者：周峰 

机构地区：[1]甘肃省庆阳市人民医院,甘肃庆阳745000

出　　处：《中国实验方剂学杂志》2013年第8期326-328,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:对比分析氟比洛芬酯联合舒芬太尼与单独使用舒芬太尼,在对肠道手术后病人所产生的镇痛作用的效果以及代谢调理作用。方法:将2011年2月-2012年7月接受过肠道肿瘤根治手术的80位病人作为实验调查的样本,随机分成舒芬太尼镇痛组(A组,n=40)和氟比涪芬酯联合舒芬太尼镇痛组(B组,n=40)。A,B组的病人在接受手术后的3 d内不得进食,只能通过肘静脉注射进行营养补充。在此时间内定时记录A,B组的病人在禁食阶段中的肿瘤坏死因子-α(TNF-α)、体温数值、皮质醇、氮平衡状况、镇痛的整体效果、白细胞介素-6(IL-6)以及肾上腺索的变化情况。结果:术后两组镇痛评分差异无统计学意义,在第3天A,B组的患者相比,第1天的镇痛效果均出现了明显的好转。术后体温、负氮平衡、TNF-α及IL-6变化B组均较A组明显(P<0.05),但是肾上腺素的数值与皮质醇数值并没有出现明显变化。结论:相比单一的使用舒芬太尼进行术后镇痛,舒芬太尼和氟比洛芬酯混合镇痛的效果并没有明显的优势,但是舒芬太尼和氟比洛芬酯混合能够起到良好的术后调理效果。Objective：To comparative analysis flurbiprofen ester joint sufentanil,and used alone sufentanil,in the patients after intestinal surgery produced by the analgesic effect and metabolic toning effect.Method：Will be in february 2011-July 2012 received intestinal cancer radical operation of 80 patients as experimental investigation of the sample,random divided into sufentanil analgesic group（group A,n=40） and fluorine than flurbiprofen ester joint sufentanil analgesic group（group B,n=40）.Due to A,B group of patients after surgery after 3 days shall not eat,can only through the week intravenous nutrition supplement.In this time logging A,B group of patients in the stage of fast the tumor necrosis factor-α（TNF-α）,body temperature numerical,cortisol,nitrogen balance,the integral effect of analgesia,interleukin-6（IL-6） and adrenal line changes.Result：The two groups of analgesic score difference was statistically significant.In the third day A,B group compared with patients who the analgesic effect of 1 day all appeared obviously improved.Postoperative body temperature,negative nitrogen balance,TNF-α and IL-6 change group B than a group obviously.But adrenaline numerical and cortex leaven numerical and no apparent change.Conclusion：Compared with the use of a single sufentanil on postoperative analgesia,sufentanil and flurbiprofen ester mixed analgesic effect and no obvious advantages,but sufentanil and flurbiprofen ester mixture can play a good postoperative conditioning effect.

关 键 词：肠道肿瘤 蛋白质代谢 术后镇痛 氟比洛芬酯 舒芬太尼 

分 类 号：R287[医药卫生—中药学]