多重耐药致导管相关性血流感染调查分析  

Clinical analysis of multidrug resistant patients with catheter-related blood stream infection

作　　者：陈萍[1] 刘丁[1] 方清永[1] 王政[1] 王豪[1] 成谣[1] 南玲[1] 黄庆玲[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所,重庆市感染控制中心,重庆400042

出　　处：《中国抗生素杂志》2013年第4期285-288,共4页Chinese Journal of Antibiotics

摘　　要：目的探讨多重耐药的导管相关性血流感染(catheter-related blood stream infection,CRBSI)发病情况,为制定和采取预防控制措施提供依据。方法对2011年1月—2012年2月住院患者中多重耐药的导管相关性血流感染病例进行统计分析。结果导管相关性血流感染发生率4.1%,其多重耐药感染发生率3.0%,主要为革兰阴性菌为91.4%,凝固酶阴性葡萄球菌、肺炎克雷伯菌、肠球菌、鲍曼不动杆菌、大肠埃希菌、耐甲氧西林金黄色葡萄球菌分别在多重耐药中占33.2%、13.6%、10.5%、10.1%、9.3%、6.4%。结论多重耐药菌对常用抗菌药物几乎全部耐药,重视病原菌监测,对控制多重耐药的导管相关性血流感染及临床合理应用抗菌药物有指导意义。Objective To investigate the characteristic for catheter-related blood stream infection caused by multidrug resistant bacteria and provide evidence for prevention and controlling measure of MDRB. Methods The statistical analysis of distribution and resistance of multidrug resistant bacteria from characteristic for catheter-related blood stream infection from January 2011 to February 2012 were retrospected. Results Incidence of nosocomial infection in patients with CRBSI was 4.1%. The CRBSI rate among the multidrug resistant bacteria was 3.0%, Most of the pathogens of CRBSI are Gram-negative bacteria for 91.4%, the rates of coagulase negative Staphylococcus, Klebsiella pneumoniae, Enterococcus species, Acinetobacter baunammii complex, Escherichia coli and Staphylococcus aureus in multidrug resistant bacteria were 33.2%, 13.6%, 10.5%, 10.1%, 9.3% and 6.4% respectively. Conclusions The major multiple drug-resistant bacteria are resistant to common-used antimicrobial drugs. Attaching importance to pathogen and drug sensitivity inspection can guide controlling multidrug resistant bacteria of CRBSI and rational using clinical antibiotics.

关 键 词：导管相关性血流感染 多重耐药菌 耐药性 

分 类 号：R378.1[医药卫生—病原生物学]