阻塞性睡眠呼吸暂停综合征并高血压患者心钠素检测的临床意义研究  

The Clinical Significance of Detection of Atrial Natriuretic Peptide in Patients with Obstructive Sleep Apnea Hypopnea Syndrome and Hypertension

作　　者：郭桂芳[1] 谭薇[1] 

机构地区：[1]潍坊医学院附属潍坊市人民医院呼吸科,山东潍坊261041

出　　处：《潍坊医学院学报》2013年第1期65-66,共2页Acta Academiae Medicinae Weifang

摘　　要：目的检测阻塞性睡眠呼吸暂停综合征(OSAHS)合并高血压患者血清心房钠尿肽(ANP)的水平,以探讨其在OSAHS合并高血压患者发病机制中的作用,以期引起OSAHS患者对早期治疗的重视。方法OSAHS患者确诊依据多导睡眠图(PSG)的检测结果。PSG检查当日,患者清醒后30min内抽取空腹外周静脉血3ml,离心后取血清,酶联免疫吸附法(ELISA法)测定ANP含量。结果 OSAHS合并高血压患者血清ANP表达水平明显升高,且其升高水平与高血压水平呈正相关。结论 ANP参与了0SAHS继发高血压的发病过程。Objective To detect the serum ANP（ atrial natriuretic peptide in the patients with OSAHS and hypertension ）levels, in order to explore its pathogenesis in patients with OSAHS and hypertensive and cause the attention of OSAHS patients for early therapy. Methods Patients with OSAHS were diagnosed according to PSG（ polysomnography） test results. Blood serum 3ml was drew half an hour after the patient awaked on the same day PSG test was took and centrifuged,and ANP was determined by enzyme-finked immunosorbent assay （ ELISA ） According to ANP data, OSAHS and hypertension was analysed. Results The expression level of serum ANP in the patients with hypertension and OSAHS is significantly elevated,and has positive correlation with levels of hypertension. Conclusion ANP is involved in the pathogenesis of OSAHS secondary hypertension.

关 键 词：阻塞性睡眠呼吸暂停综合征 高血压 心钠素 

分 类 号：R765[医药卫生—耳鼻咽喉科] R766[医药卫生—临床医学]