特发性嗅觉减退患者嗅球体积与嗅沟深度的研究  

Olfactory bulb volume and depth of olfactory sulcus in patients with idiopathic olfactory loss

作　　者：张金玲[1] 杭伟[1] 刘钢[1] 

机构地区：[1]天津市环湖医院耳鼻咽喉科,300060

出　　处：《中华耳鼻咽喉头颈外科杂志》2013年第4期279-283,共5页Chinese Journal of Otorhinolaryngology Head and Neck Surgery

基　　金：天津市卫生局科技基金项目（09KY18）

摘　　要：目的分析特发性嗅觉减退患者嗅球体积、嗅沟深度与嗅觉功能的相关性。方法选取特发性嗅觉减退患者（测试组）及无嗅觉减退的健康受试者（对照组）各40例，应用T＆T嗅觉测试法检查所有受试者的嗅觉功能，并行嗅球体积、嗅沟深度的MRI检查。1年后测试组来院随访，并行T＆T嗅觉检查及MRI嗅球体积及嗅沟深度检查，并与初次检查结果进行比较。结果测试组左右两侧嗅球体积[分别为（30．31±4．07）、（30．82±4．14）mm。]及平均嗅球体积[（30．53±4．10）mm。]均明显小于对照组[分别为（49．56±7．19）、（49．84±7．25）、（49．73±7．21）mm。]，差异有统计学意义（t值分别为8．122、8．274、8．231，P值均〈0．01）。测试组与对照组左右两侧嗅沟深度及平均嗅沟深度差异无统计学意义（t值分别为0．998、1．017、1．001，P值均〉0．05）。测试组嗅觉识别阈与嗅球体积呈负相关（r=一0．53，P〈0．05），与嗅沟深度无关（r=-0．19，P〉0．05）。1年后复查，测试组12例嗅觉功能出现不同程度恢复，左右两侧嗅球体积及平均嗅球体积略有增大，但与1年前比较，差异无统计学意义（t值分别为0．831、0．864、0．826，P值均〉0．05），28例嗅觉功能和嗅球体积无明显变化。结论特发性嗅觉减退患者嗅球体积减小，嗅沟深度不变；嗅觉功能与嗅球体积具有相关性，与嗅沟深度无关。随着病程的发展，部分特发性嗅觉减退患者嗅觉功能有一定程度的恢复，嗅球体积略有增大．Objective To analyze the correlation between olfactory bulb（OB） volume with depth of olfactory suleus （O$） and olfaetory function in patients with idiopathic olfactory loss （IOL）. Methods Forty patients with IOL and forty normal controls were compared in terms of olfactory function T＆T testing and magnetic resonance imaging （ MRI, observation of OB volume and depth of OS）. T＆T testing and MRI were performed again after a year in 40 IOL patients, the results were compared with the first time. Results OB volume of left side in IOL patients was （30. 31 -＋4. 07） mm3, right side was （30. 82 -＋4. 14） mm3, average OB volume was （30. 53 ~4. 10）ram3 ; OB volume of left side in normal controls was （49. 56 ~7.19）mm3, right side was （49. 84 -＋ 7. 25 ）mm3, average OB volume was （49. 73 ~ 7.21 ）mm3. OB volume was lower in IOL patients as compared to eontrols（t value were 8. 122, 8. 274, 8. 231, all P 〈0. 01 ）. OS depth study revealed no statistical different between IOL patients and controls （t value were 0. 998, 1. 017, 1. 001, all P 〉 0. 05 ）. Olfactory discriminate threshold was negatively correlated with OB volume in IOL patients （ r -- -0. 53, P 〈0. 05）. There was no correlation with the depth of O$（r = -0. 19, P 〉0. 05）. Among 40 IOL patients, when followed-up, 12 showed increased in OB volume and olfactory function after a year, but no statistical difference was found with the first time（ t value were 0. 831, 0. 864, 0. 826, all P 〉 0. 05 ）. The other 28 patients showed no significant changes of OB volume and olfactory function. Conclusions The OB volume was lower in IOL patients as compared to normal controls. The depth of OS showed no significant changes in IOL patients. The OB volume was correlated with olfactory function. The depth of OS did not correlated with the olfactory function. Some IOL patients showed increased OB volume and improved olfactory function with the development of the disease.

关 键 词：嗅觉障碍 嗅球 嗅通路 磁共振成像 

分 类 号：R765[医药卫生—耳鼻咽喉科]