A novel pressure difference-induced perforation aortic stent-grafts system： an experimental study  

作　　者：DENG Guo-yu ZHOU Jian LU Qing-sheng WANG Lu HOU Le-wei DONG Jian WANG Jian-nan ZHANG Shu-ming ZHAO Zhi-qing JING Zai-ping 

机构地区：[1]Department of Vascular Surgery ,Changhai Hospital, Second Military Medical University, Shanghai 200433, China [2]Department of Surgery , Changhai Hospital, Second Military Medical University, Shanghai 200433, China [3]College of Textiles, Donghua University, Shanghai 200433, China

出　　处：《Chinese Medical Journal》2013年第7期1264-1268,共5页中华医学杂志（英文版）

基　　金：DENG Guo-yu and ZHOU Jlan contributed equally to this work. This study was supported by the grants from National Natural Science Foundation of China （No. 30972942, No. 81273522, and No. 81270386）.

摘　　要：Background Most of endovascular stent-graft modifications to preserve side branch must be customized according to extensive pre-operative assessment, which may not be possible in many hospitals and emergency settings. The study was to develop a novel stent-grafts system that would allow in situ ＂fenestration＂, with less reliance on preoperative imaging. Methods The magnitude of pressure difference （PD） between left subclavian artery （LSA） and aortic arch were measured in 12 experimental pigs. Changes of PD before and after LSA was covered were analyzed respectively. The novel stent graft was made by multi-dimensional and multiple textiles forming technology. According to the PD measurement in pigs, we evaluated the feasibility of the stent-graft in a mock circulation system. Results In pigs, the blood pressure of aortic arch was significantly higher than that of LSA after it was covered （P 〈0.001） and PD was （42.78±5.17） mmHg. After target vessel was covered and when PD between the LSA and aorta reached the magnitude measured in pigs, contrast media oozed from the cranny of graft to the LSA, which was generated by sliding and deformation of yarns of novel stent-graft. Conclusions The study proposes the design of pressure difference-induced perforation aortic stent-grafts system and verifies that the PD between LSA and aortic arch is high enough to allow in situ ＂fenestration＂ by stent graft made by multi-dimensional and multiple textiles forming technoloav.Background Most of endovascular stent-graft modifications to preserve side branch must be customized according to extensive pre-operative assessment, which may not be possible in many hospitals and emergency settings. The study was to develop a novel stent-grafts system that would allow in situ ＂fenestration＂, with less reliance on preoperative imaging. Methods The magnitude of pressure difference （PD） between left subclavian artery （LSA） and aortic arch were measured in 12 experimental pigs. Changes of PD before and after LSA was covered were analyzed respectively. The novel stent graft was made by multi-dimensional and multiple textiles forming technology. According to the PD measurement in pigs, we evaluated the feasibility of the stent-graft in a mock circulation system. Results In pigs, the blood pressure of aortic arch was significantly higher than that of LSA after it was covered （P 〈0.001） and PD was （42.78±5.17） mmHg. After target vessel was covered and when PD between the LSA and aorta reached the magnitude measured in pigs, contrast media oozed from the cranny of graft to the LSA, which was generated by sliding and deformation of yarns of novel stent-graft. Conclusions The study proposes the design of pressure difference-induced perforation aortic stent-grafts system and verifies that the PD between LSA and aortic arch is high enough to allow in situ ＂fenestration＂ by stent graft made by multi-dimensional and multiple textiles forming technoloav.

关 键 词：AORTA left subclavian artery STENT-GRAFT pressure difference mock circulation 

分 类 号：TS101.923[轻工技术与工程—纺织工程] TU758.15[轻工技术与工程—纺织科学与工程]