Important immunohistochemical markers for identifying sweat glands  

作　　者：LEI Yong-hong LI Xue ZHANG Jin-qian ZHAO Jing-yu 

机构地区：[1]Wound Healing and Cell Biology Laboratory, the First Affiliated Hospital, Chinese People's Liberation Army General Hospital, Beijing 100853, China [2]The Cardiology Department, Tangdu Hospital, the Fourth Military Medical University, Xi'an, Shaanxi 710038, China [3]Ditan Hospital, Beiiing 100011, China

出　　处：《Chinese Medical Journal》2013年第7期1370-1377,共8页中华医学杂志（英文版）

基　　金：This review was supported by the General Program of National Natural Science Foundation of China （Nos. 30870991 and 30672176）, the Key Program of National Natural Science Foundation of China （No. 30230370）, and the Major State National Basic Science and Development Program （No. 2005CB522603）.

摘　　要：he major adnexal structures of the skin, the sweat glands, regulate the body temperature. There are twotypes of sweat glands in the human body, the eccrine type, which produces the NaCl-rich solution in response to heat, and the apocrine type, which releases a lipid-rich secretion. Human sweat glands have many immunohistochemical markers which have close relationship with sweat-related diseases. Recently, although numerous immunohistochemical markers appeared in sweat glands, these biomarkers scattered in the oceans of literature without a systemic review for the relationship between the immunohistochemical marker and their functions in the counterparts of the sweat glands. It is important for identifying sweat gland-derived neoplasms that originate from or differentiate into the ducts or secretory elements of the sweat glands by immunohistochemical markers. Therefore, it is necessary to make a review of the immunohistochemical markers systematically. Actually, we try to classify the immunohistochemical markers of the sweat glands into four groups according to their protein characters and the functions associated with their presumed physiological counterparts of the sweat apparatus.he major adnexal structures of the skin, the sweat glands, regulate the body temperature. There are twotypes of sweat glands in the human body, the eccrine type, which produces the NaCl-rich solution in response to heat, and the apocrine type, which releases a lipid-rich secretion. Human sweat glands have many immunohistochemical markers which have close relationship with sweat-related diseases. Recently, although numerous immunohistochemical markers appeared in sweat glands, these biomarkers scattered in the oceans of literature without a systemic review for the relationship between the immunohistochemical marker and their functions in the counterparts of the sweat glands. It is important for identifying sweat gland-derived neoplasms that originate from or differentiate into the ducts or secretory elements of the sweat glands by immunohistochemical markers. Therefore, it is necessary to make a review of the immunohistochemical markers systematically. Actually, we try to classify the immunohistochemical markers of the sweat glands into four groups according to their protein characters and the functions associated with their presumed physiological counterparts of the sweat apparatus.

关 键 词：sweat glands immunohistochemical marker anttgentc epitopes 

分 类 号：R392.1[医药卫生—免疫学]