盐酸米多君治疗儿童体位性心动过速综合征时间-疗效分析  

A time-effect analysis of postural orthostatic tachycardia syndrome treated with midodrine hydrochloride in children

作　　者：邓文军[1] 杨锦艳[1] 刘严玲 杜军保[1] 金红芳[1] 

机构地区：[1]北京大学第一医院儿科,北京100034 [2]荼陵疾病预防与控制中心,湖南茶陵412400

出　　处：《中国实用儿科杂志》2013年第4期274-276,共3页Chinese Journal of Practical Pediatrics

基　　金：国家十二五科技支撑计划(2012BA103B03);首都特色研究项目(D10100050010059)

摘　　要：目的分析盐酸米多君治疗体位性心动过速综合征(POTS)患儿的时间-疗效关系,以探讨盐酸米多君治疗POTS小儿的最佳用药周期。方法随访2005—2011年北京大学第一医院104例接受盐酸米多君治疗6个月的POTS患儿,依据治疗效果与用药时间的关系进行卡方检验并绘制时间-疗效曲线。结果依据盐酸米多君治疗时间,其累计有效率分别为1个月19.23%,2个月48.08%,3个月69.23%,4个月73.08%,5个月74.04%,6个月75.96%。卡方检验统计显示盐酸米多君治疗疗程为1个月及2个月时,其累计有效率与治疗疗程为3个月时的累计有效率相比较,差异有统计学意义(P<0.05),而治疗疗程为4、5和6个月时其累计有效率与治疗疗程为3个月时的累计有效率相比较,其差异均无统计学意义(P>0.05)。结论盐酸米多君治疗POTS小儿满3个月才能达到其最佳疗效,延长治疗疗程至6个月并不能显著提高治疗效果。Objective The time-effect relationship in treating postural orthostatic tachycardia syndrome （POTS） of children with alpha receptor agonist midodrine hydrochloride was analyzed to explore the optimum course of treatment for POTS children. Methods A total of 104 cases of the POTS children were studied from 2005 to 2011 in Peking University First Hospital. A chi-square test was used to evaluate the relationship between effect and time of medication, and the time-effect curve was constructed. Results According to the 104 cases, the time accumulative total efficacy for 1 month, 2 months, 3 months, 4 months, 5 months and 6 months were 19.23%, 48.08%, 69.23%, 73.08%, 74.04% and 75.96%, respectively. The time accumulative total efficacy for 3 months was higher than that for 1 month or 2 months （P〈0.05）, but there was no difference in the efficacy among 4 months, 5 months and 6 months treatment and with 3 months treatment. Conclusion It has the best treatment efficacy when the course of treatment for POTS children with midodrine hydrochloride is 3 months, and prolonging the duration of treatment does not significantly improve the therapeutic effect.

关 键 词：体位性心动过速综合征 盐酸米多君 时间-疗效曲线 

分 类 号：R72[医药卫生—儿科]