干预肠道菌群对肠易激综合征症状学影响的前瞻性研究  

Prospective study on the effection of symptomatology of irritable bowel syndrome by intervention the intestinal flora

作　　者：张学娜[1] 金世禄[2] 刘宝珍[2] 齐艳美[2] 

机构地区：[1]滨州医学院临床学院,滨州256603 [2]滨州医学院附属滨州市人民医院,滨州256610

出　　处：《现代仪器与医疗》2013年第2期34-37,共4页Modern Instruments & Medical Treatment

摘　　要：目的 观察干预肠道菌群失调对预防和减轻远期肠易激综合征症状的作用，探讨菌群失调与IBS的关系。方法 （1）收集2010年12月－2012年2月我院确诊的腹泻型肠易激综合征（IBS-D）患者，给予常规治疗症状消失后，随机分为干预组和观察组各60例；（2）入选后，每4~6周检测粪便菌群，出现菌群失调的患者，干预组给予菌群调节制剂治疗，观察组仅观察；（3）当出现症状时，记录患者IBS症状学积分，未出现症状者做无症状记录。结果 102例患者完成试验。（1）观察组症状发生率明显高于干预组（P〈0.05）；（2）有菌群失调者症状发生率明显高于无菌群失调者（P〈0.05）；（3）有菌群失调者发生症状时症状学总分、腹痛时间、腹痛频率及腹胀比例明显高于无菌群失调者（P〈0.05），而大便形状异常、排便过程异常及黏液便比例则无统计学意义（P〉0.05）。结论 肠道菌群失调与IBS存在一定关系，肠道菌群失调可能是IBS重要的发病原因之一。因此，恢复正常肠道菌群有助IBS的预防和治疗。Objective To explore the relationship Between imbalance of intestinal flora and IBS by observing whether intervention of the intestinal flora can prevent and relief the irritable bowel syndrome subsequently. Methods （1）120patientswhosuffereddiarrhea-predominantIBS（IBS-D）from December2010to February 2012weredividedinto twogroupsrandomly after beingcuredbyconventionaltreatment, intervenegroupandobservationgroup. （2）The intestinal flora were monitored every 4-6weeks by checking the fecal bacteria. As for those who appears intestinal flora imbalance, the intervene group will give treatment and the observation group will stay for further observation. （3）When symptoms appear,record the patients’ IBS symptomatology score.Otherwise,record no symptoms. Results There are 102patients finished the test according to the requirements. （1）The recurrence rate of observation group is higher than intervene group（P〈0.05）. （2）The recurrence rate of patients with intestinal flora imbalance is higher than the patients without intestinal flora imbalance（P〈0.05）. （3）The patients with intestinal flora imbalance which total symptomatic scores, abdominal pain time, abdominal pain frequency and abdominal bloating proportion was higher than the patients with no intestinal flora imbalance. The difference between two groups was significant（P〈0.05）, but there were no significant difference in the rate of exceptionalshapeofstool, exceptionaldefecation and sticky fluid and stool （P〉0.05）. Conclusion The imbalance of intestinal flora related to IBS,itmaybeoneoftheimportantcausesof IBS.Therefore,restoring the normal intestinal flora contributes to the prevention of IBS.

关 键 词：肠易激综合症 肠道菌群干预 症状学 前瞻性研究 

分 类 号：R442.8[医药卫生—诊断学]