地特胰岛素联合二甲双胍或加用瑞格列奈治疗口服降糖药血糖控制不佳的2型糖尿病患者的疗效观察  

Effect of insulin detemir combined with metformin or the sequential add-on treatment with repaglinide on T2DM patients with poor glycemic controls

作　　者：唐建东[1] 李清楚[1] 康志强[1] 何丽[1] 罗方[1] 雷龙涛[1] 

机构地区：[1]郑州大学附属郑州中心医院内分泌科,450007

出　　处：《中国糖尿病杂志》2013年第4期339-341,共3页Chinese Journal of Diabetes

摘　　要：目的观察地特胰岛素(Det)联合二甲双胍或瑞格列奈,治疗口服降糖药(OAD)血糖控制不佳的T2DM患者的疗效。方法选取OAD血糖控制不佳的T2DM患者42例,给予Det联合二甲双胍治疗,血糖未达标者再加用瑞格列奈。患者分为Det联合二甲双胍组(A组)与Det联合二甲双胍加用瑞格列奈组(B组),分别测定治疗前后SBP、DBP、BMI、TG、TC、LDL-C、HDL-C、HbA1c、平均血糖水平(MBG)及一日内平均血糖波动幅度(MAGE)。结果治疗后两组TG、HbA1c、MBG、MAGE均改善。结论 Det联合二甲双胍或加用瑞格列奈能有效改善OAD控制不佳的T2DM患者的血糖控制情况。Objective To observe the effect of insulin detemir combined with metformin or sequential add-on treatment with repaglinide on the T2DM patients with poorly controlled blood glucose from oral anti-diabetes drugs （OAD）. Methods Forty-two T2DM patients with poorly controlled blood glucose were observed. They were treated with insulin detemir combined with metformin, in case the blood glucose was not on the targeted level, the sequential treatment with repaglinide would be added. The patients in group A was treated with insulin detemir combined with metformin, and those in group B treated with insulin detemir plus metformin and repaglinide in the added treatment. Before and after treatment, the SBP, DBP, BMI, HbAlc, TG, TC, HDL-C, LDL-C, and mean blood glucose （MI~） levels, and the mean amplitude of glycemic excursions （MAGE） were determined in all patients for 12 weeks for comparison. Results After the treatment, the HbA1 c and MI~ levels and MAGE of both groups were significantly decreased. Conclusion Insulin detemir combined with metformin or sequential add-on treatment with repaglinide can significantly improve the glycemic control of the T2DM patients with poorly controlled blood glucose from OAD.

关 键 词：糖尿病 2型 血糖控制 地特胰岛素 二甲双胍 瑞格列奈 

分 类 号：R587.1[医药卫生—内分泌]