氨氯地平联合厄贝沙坦对糖尿病合并高血压患者血压晨峰现象影响的观察  

Effect of combination of amlodipine and irbesarta on morning blood pressure surge in diabetic patients with hypertension

作　　者：朱一帆[1] 魏曦[1] 陈茜[1] 李春陵[1] 袁志柳[1] 王静[1] 

机构地区：[1]贵州省人民医院干部医疗科,贵阳550002

出　　处：《中国糖尿病杂志》2013年第4期342-344,共3页Chinese Journal of Diabetes

摘　　要：目的探讨氨氯地平联合厄贝沙坦对糖尿病合并高血压患者血压晨峰(MBPS)现象的影响。方法将80例患者随机分为实验组(A组)和对照组(B组),观察服药前及服药后4、8周清晨血压的变化,比较4、8周后两组MBPS下降程度。结果 4、8周后两组MBPS较治疗前均下降(P<0.05),A组下降幅度大于B组(P<0.01)。8周后,MBPS控制有效率A组为92.5%,B组为60%(P<0.05)。结论氨氯地平联合厄贝沙坦较单独使用氨氯地平更能有效地控制糖尿病合并高血压患者MBPS现象。Objective To study the effect of amlodipine and irbesarta in combination on morning blood pressure surge （MBPS） in diabetic patients with hypertension. Methods Eighty diabetic patients with hypertension were randomized into experimental group （amlodipine＋ irbesarta） and control group （amlodipine）. The observation on the changes in morning blood pressure surge （MBPS） at the 42 and 8% weeks after medication theray respectively was carried out to compare the decrement of MBPS between the two groups. Results On four and eight weeks after medication, there was a decrement of MBPS in both groups （P〈0. 05）, while the deerement in the experimental group was more significant than was in the control group （P〈0. 01）. On eight weeks after medication, the effective controlling rate of blood pressure in the experimental group was 92. 5% ,higher than 60% in the control group （P〈0.05）. Conclusion Amlodipine in combination with irbesartan is more effective than is amlodipine only in controlling MBPS in the diabetic patients with hypertension.

关 键 词：氨氯地平 厄贝沙坦 糖尿病 高血压 血压晨峰 

分 类 号：R544.1[医药卫生—心血管疾病]