苦参素联合干扰素α治疗慢性乙型肝炎疗效观察及对患者肝纤维化指标与细胞免疫状态的影响  

Observation of clinical efficacy of combination therapy of interferon α and kurarinone in treatment of chronic hepatitis B and its effects on hepatic fibrosis and cellular immunity

作　　者：傅金满[1] 张炜[1] 

机构地区：[1]台州医院感染科,浙江临海317000

出　　处：《中华医院感染学杂志》2013年第8期1777-1779,共3页Chinese Journal of Nosocomiology

摘　　要：目的探讨苦参素联合干扰素α治疗慢性乙型肝炎疗效及对肝纤维化与细胞免疫的影响。方法将52例慢性乙肝患者平均随机分为对照组与治疗组,对照组接受干扰素α-2b治疗,治疗组在对照组治疗基础上接受苦参素治疗,观察并比较两组患者治疗前后肝功能、肝纤维化指标改善、HBeAg、HBsAg以及HBV-DNA阴转、CD4+、CD8+以及NK细胞亚群变化。结果与治疗前相比,两组患者肝功能、肝纤维化指标均显著改善(P<0.05),但以治疗组改善更为显著(P<0.05);与对照组相比,治疗组患者HBeAg、HBsAg以及HBV-DNA阴转率显著升高(P<0.05);与对照组相比,治疗组治疗后CD4+T及NK细胞比例显著升高,CD8+T细胞比例显著降低,CD4+/CD8+比值显著升高,差异均有统计学意义(P<0.05)。结论苦参素联合干扰素治疗慢性乙型肝炎药物配伍合理,疗效肯定,能够显著改善患者肝纤维化以及细胞免疫状态,减轻纤维化。OBJECTIVE To explore the clinical efficacy of combination therapy of interferon α and kurarinone in treatment of chronic hepatitis B and its effects on indicators of hepatic fibrosis and cellular immunity.METHODS A total of 52 patients with chronic hepatitis B were selected and randomly divided into the control group and the treatment group.The control group received the treatment of interferon,while the treatment group received the combination therapy of interferon and kurarinone.Hepatic functions,indicators of hepatic fibrosis,status of cellular immunity,and overcast rate of HBeAg,HBsAg and HBV-DNA were observed and compared between the two groups before and after treatments.RESULTS Hepatic functions and indicators of hepatic fibrosis were improved significantly after the treatment for all the patients（P0.05）,but more significantly in the treatment group（P0.05）.Compared with the control group,the overcast rates of HBeAg,HBsAg and HBV-DNA of the treatment group were significantly higher（P0.05）.Compared with the control group,the proportion of CD4＋ and NK increased significantly,proportion of CD8＋ decreased and the ratio of CD4＋/CD8＋ increased significantly after treatment in the treatment group,the differences were all statistically significant（P0.05）.CONCLUSION Combination therapy of interferon and kurarinone is suitable for the treatment of chronic hepatitis B,showing confirmed clinical effect,which can improve the cellular immunity and mitigate the hepatic fibrosis.

关 键 词：慢性乙型肝炎 苦参素 干扰素 肝纤维化 细胞免疫 

分 类 号：R512.62[医药卫生—内科学]