下肢静脉溃疡表面病原菌感染分析  

Pathogens causing infections on the surface of venous leg ulcers

作　　者：孙一峰[1,2] 唐黎明[1,2] 

机构地区：[1]绍兴市人民医院 [2]浙江大学绍兴医院普外科,浙江绍兴312000

出　　处：《中华医院感染学杂志》2013年第8期1830-1831,1879,共3页Chinese Journal of Nosocomiology

摘　　要：目的探讨病原菌感染对下肢静脉溃疡愈合的影响,为临床治疗下肢静脉溃疡提供依据。方法选择2009年1月-2012年1月590例下肢静脉溃疡患者,将下肢静脉溃疡完全愈合的398例患者为完全愈合组,未完全愈合的192例患者为未完全愈合组;治疗前获取其溃疡的组织样本,治疗后进行6个月随访,对两组患者的治疗前溃疡组织样品进行病原菌的检测,探讨病原菌感染对下肢静脉溃疡的影响。结果两组病例组织样本中均检出病原菌,完全愈合组金黄色葡萄球菌、表皮葡萄球菌、铜绿假单胞菌检出阳性率分别为66.7%、10.3%、40.45%,与未完全愈合组比较,差异无统计学意义;完全愈合组的细菌总量明显少于未完全愈合组,差异有统计学意义(P<0.05)。结论单类细菌含量与下肢静脉溃疡的愈合无直接关系,但是总体的细菌总量与溃疡愈合却有很大关联,应加强临床上对下肢静脉溃疡患者溃疡面的防护,避免细菌滋生影响溃疡面愈合。OBJECTIVE To discuss the influence of bacterial infections on the healing of venous leg ulcers so as to provide basis for the clinical treatment of venous leg ulcers.METHODS A total of 590 cases of venous leg ulcer patients were selected and their ulcer tissue samples were sampled before the treatment.The 398 patients whose venous leg ulcers were totally cured were set as the complete heal group,the others as the incomplete heal group.The tissue samples of two groups were studied for the bacteria species.A six-month follow-up was conducted after the treatment,then the influence of bacterial infection for the union of venous leg ulcers was discussed.RESULTS The pathogens were detected in all of the tissue samples of the two case groups.In the complete heal group,the positive rates of Staphylococcus aureus,Staphylococcus epidermidis,and Pseudomonas aeruginosa were 66.7%,10.3%,and 40.45%,respectively,and the difference in the positive rate between the complete heal group and the incomplete heal group was not statistically significant.The total bacterial colony count was significantly less in the complete heal group than in the incomplete heal group.The difference was statistically significant（P0.05）.CONCLUSION There is no direct relation between the content of the single species of bacteria and the venous leg ulcer,but the total content is closely related to the healing of the venous leg ulcer.We should strengthen the protection of the surface of venous leg ulcer so as to avoid the bacterial growth.

关 键 词：下肢静脉溃疡 表面细菌 细菌感染 

分 类 号：R181.32[医药卫生—流行病学]