主成分分析辅助高效液相色谱法测定双黄连胶囊的溶出度  

Dissolution determination of Shuanghuanglian capsules by HPLC analysis assisted with principal component analysis

作　　者：张伟泉[1] 郭怀忠[1,2] 张小倩[1] 刘前义[1] 

机构地区：[1]河北大学药学院,河北保定071002 [2]河北省药物质量分析控制重点实验室,河北保定071002

出　　处：《中国中药杂志》2013年第7期985-989,共5页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(20905019);河北省自然科学基金项目(B2010000209);河北大学自然科学基金项目(2007-111)

摘　　要：目的:建立一种基于自身对照原理的用于评价双黄连胶囊溶出度的分析方法。方法:利用主成分分析(PCA)结合高效液相色谱法,测定双黄连胶囊的溶出度。结果:回归方程的线性关系良好,校正样品(QA)和质控样品(QC)的平均回收率均不低于96.0%,不同厂家和同厂家不同批次双黄连胶囊的溶出曲线均存在较大差异。结论:该方法能较好地评价双黄连胶囊的溶出状况,同时也有望用于其他中药口服固体制剂的溶出度评价。Objective： To develop a quality analysis method based on serf-reference principal for dissolution determination of Shuanghuanglian capsules. Method： Dissolution of Shuanghuanglian capsules was determined by principal component analysis consociated HPLC method. Result： The liner of regression equation was good. The average recovery rates of quality assurance samples （QA） and quality control samples （QC） were all no less than 96.0%. Dissolution curves of Shuanghuanlian capsules of different manufacturers and different batches of the same manufacturer had obvious disparity. Conclusion： The method can better evaluate the dissolution conditions of Shuanghuanglian capsules. The prospect of the method is expected for assessing the dissolution of other oral solid dosage of traditional Chinese medicines.

关 键 词：双黄连胶囊 主成分分析 HPLC 溶出度 自身对照 

分 类 号：R286.0[医药卫生—中药学]