康复期重度烧伤患者抑郁的血浆β-内啡肽水平表达  

Beta Endorphins Level Expression in Severe Burn Patients with Depression in Period of Rehabilitation

作　　者：程华[1] 李瑞俊[1] 梁小玲[1] 黄小冰[1] 

机构地区：[1]广东医学院附属医院烧伤科,广东省湛江市524001

出　　处：《医学理论与实践》2013年第8期985-986,990,共3页The Journal of Medical Theory and Practice

摘　　要：目的:探讨康复期重度烧伤患者血浆beta-内啡肽(β-EP)水平的变化及血β-EP表达与抑郁状态的关系。方法:共36例康复期重度烧伤患者。抽取早晨空腹外周静脉血,以酶联免疫ELISA检测两组患者血浆β-EP浓度变化。根据抑郁自评量表(SDS)评估分为抑郁组及对照组进行配对研究。结果:重度烧伤患者β-EP浓度有性别差异(r=-0.416,P=0.012),而且高于正常人群表达;抑郁状态下患者血浆β-EP浓度比无抑郁者高,分别为[(722.7±395.7)pg/ml VS(700.5±269.8)pg/ml,t=-7 908.5,P<0.01];抑郁程度增高,其血浆β-EP呈下降趋势。结论:康复期重度烧伤患者血浆beta-内啡肽(β-EP)呈高水平表达,与伤后患者抑郁状态有关。Objective： Explore the variation of expression of plasma beta-endorphins （β-EP） level and pathology of depression disorder in severe burn patients in the period of rehabilitation. Methods： 36 subjects were chosen. Their fasting venous blood was drawn and centrifuged, the separated plasma were stored at --80℃ until assay. The concentration of the β-EP were tested by ELISA kit. The depression assessment were evaluated by SDS. Samples were matched pairs were identified. Results：The concentration of β-EP appeared gender difference（r= -0. 416, P=0. 012）, and higher than that of normal peopl. The eoneentration of β-EP in patients with depression were higher then those without it, which were（722. 7±395.7）pg/ml VS （700. 5±269. 8）pg/rnl,（t=-7 908. 5,P〈0. 01）. Its＇concentration had trended down over the increasing of the severity of depression. Conclusion：The level of plasma β-EP were high in severe burn patients with depression in the period of rehabilitation.

关 键 词：烧伤 抑郁 beta-内啡肽 

分 类 号：R644[医药卫生—外科学]