耐多药结核病危险因素logistic回归分析  

Logistic Analysis on Risk Factors of Multidrug-resistant Tuberculosis

作　　者：张玉[1] 侯双翼[2] 杨成凤[2] 周纯辉[2] 皮琦[2] 童叶青[2] 王小靖[2] 叶建君[2] 

机构地区：[1]武汉科技大学医学院,430065 [2]湖北省疾病预防控制中心,430079

出　　处：《中国卫生统计》2013年第2期190-191,195,共3页Chinese Journal of Health Statistics

基　　金：国家科技重大专项(2009ZX10003-019)

摘　　要：目的了解湖北省耐多药结核病产生的危险因素,为预防和控制耐多药结核病提供依据。方法采用1:1配对病例对照研究的方法,在湖北省五个地市结核病防治所整群抽取病例和对照各345例进行问卷调查,计算OR值和95%CI,并用条件logistic回归分析进行多因素分析。结果在单因素分析中,患者职业为农民、家庭人均月收入低、经常饮酒、既往有结核病史、有结核病接触史、既往治疗不规则或失败,其OR值分别为4.591、1.761、1.593、11.082、7.656、8.481(P值均<0.05)。在多因素分析中,既往有结核病史是湖北省耐多药结核病发生的主要危险因素。结论加强对有既往结核病史患者的治疗和管理,并针对其他危险因素采取措施对降低耐多药结核病疫情有重要意义。Objective To investigate the risk factors associat- ed with multidrug-resistam tuberculosis （MDR-TB） in Hubei Province. Methods Using pair matched case-control study, 345 MDR-TB cases and 345 controls （ pairs matched for sex and age） were randomly sampled from Tu-berculosis Dispensary in five cities; subjects were face-to-face in- terviewed by trained personals; data was analyzed with conditional logistic regression. Results Single-variable analysis showed that occupation, ca- pita income, often drinking, previous history of tuberculosis, previous histo- ry of exposure to tuberculosis were associated with incidence of MDR-TB, with the Odds Ratios（OR） of 4.591, 1.761, 1.593, 11.082,7.656, 8.481, all P 〈 0. 05, but only previous history of tuberculosis entered into multiple regression model. Condusion The epidemic situation of MDR- TB would be controlled with well managed tuberculosis and with measure against other risk factors.

关 键 词：耐多药结核病 危险因素 LOGISTIC回归分析 

分 类 号：R52[医药卫生—内科学]