2,4-二氨基苯基胆甾醚的合成  

Synthesis of 2,4-Diaminophenyl Cholesteryl Ether

作　　者：赵昀[1] 胡美玲[1] 吉轩[1] 张鹏[1] 张昭[1] 

机构地区：[1]山西大学化学化工学院,山西太原030006

出　　处：《精细化工》2013年第4期465-467,共3页Fine Chemicals

基　　金：山西大学本科生科研训练资金资助项目(2012010056)~~

摘　　要：以溴苯为原料,经硝化后,在四丁基溴化铵相转移催化剂作用下与胆固醇成醚、硝基还原反应得到2,4-二氨基苯基胆甾醚,并对成醚反应的条件进行了优化。较佳合成反应条件是:以甲苯为溶剂,n(2,4-二硝基溴苯)∶n(胆固醇)=1.55∶1,反应温度25℃,w(NaOH)=50%,反应时间3.5 h,产率为72%。所得中间体和目标化合物经过红外光谱和核磁波谱的表征。Using bromobenzene and cholesterol as starting materials, 2,4-diaminophenyl cholesteryl ether was synthesized by nitration, reduction and etherification reactions. The optimum reaction conditions of etherification were determined. The preferred reaction conditions are： n （2, 4- dinitrobromobenzene） ：n（cholesterol） = 1.55：1 ,w（NaOH） = 50% ,reacting for 3.5 h at 25 with toluene as solvent. The yield of 2,4-diaminophenyl cholesteryl ether is 72%. The structures of all the products were characterized by means of IR and 1HNMR spectra.

关 键 词：胆甾醇 2 4-二氨基苯基胆甾醚 四丁基溴化铵 溴苯 精细化工中间体 

分 类 号：O621.3[理学—有机化学]