生物介质内形成的金属基生物微粒:冲击和挑战  

Metal-Based Particles in Biological Media:Impact and Challenge

作　　者：王夔[1] 杨晓改[1] 

机构地区：[1]北京大学药学院化学生物学系,北京100191

出　　处：《化学进展》2013年第4期457-468,共12页Progress in Chemistry

基　　金：国家自然科学基金项目(No.21277006)资助

摘　　要：在体液、组织、生物界面等生物介质中广泛存在着自发形成的金属基生物微粒,其中包括在体内原位生成的和异位转化的内源性微粒,也包括外源性微粒在体内被修饰转化所产生的次生微粒。这些在体内形成的微粒的粒径在纳米至微米级之间,它们大都参与生理、病理和毒理过程。但是目前缺乏对它们的生物效应与其形成、结构、性质相关性的研究。本文列举了有关金属基生物微粒的诸多现象和对它们的初步认识,提出了这方面有待解决的问题,这方面的研究结果将对环境、健康、疾病控制等领域的研究提供新思路。Spontaneously formed metal-based bioparticles, such as those formed in situ and intrinsic particles transformed ex situ, as well as in vivo modified and transformed extrinsic particles, are often present in the biogical media including body fluids, tissues and biointerfaces. The size of these particles are between nano- and micro- meters. Most of them are involved in the physiological, pathological and toxicological processes. Up to now, however, there is a lack of research on the relationship between the biological effects and the formation, structure and properties of these particles. The present article lists some facts and preliminary understanding about these metal-based bioparticles. Some research areas to be investigated are also proposed. The findings in these areas may provide the insight into the studies on the environment, health, disease control and so on.

关 键 词：金属基生物微粒 生物介质 生物效应 

分 类 号：O614[理学—无机化学] Q519[理学—化学]