mTORC2信号通路调节上皮细胞钠通道的研究进展  

Research advance of mTORC2 signaling pathway in regulation of epithelial sodium channel

作　　者：瞿利元[1] 王导新[1] 

机构地区：[1]重庆医科大学附属第二医院呼吸科,400010

出　　处：《国际呼吸杂志》2013年第6期466-469,共4页International Journal of Respiration

摘　　要：哺乳动物雷帕霉素靶蛋白（mammaliantargetofrapamycin，mTOR）是一种丝氨酸／苏氨酸蛋白激酶，属于磷脂酰肌醇激酶相关激酶蛋白质家族成员。roTOR进化上高度保守，可整合营养、能量及生长因子等多种细胞外信号，在细胞生长、增殖、凋亡及自噬等过程中发挥极为重要的作用。在生物体内，mTOR有2种多蛋白复合物：mTORCl和mTORC2，目前mTORC1信号通路与肿瘤的关系研究较多，而对mTORC2的研究相对较少，近年来有研究发现mTORC2信号通路参与了上皮细胞钠通道的调节作用。Mammalian target of rapamyein （mTOR）, a serine/threoine protein kinase, is a member of phosphatidy linositol kinase-related kinase family. It is highly conserved in evolution, which can integrate diverse extracelluar signals, such as nutrients, energy,and growth factors, mTOR plays a critical role in the processes of cell growth, proliferation, apoptosis, and autophagy. In vivo, mTOR forms two distinct muhiprotein complexes： mTORC1 and mTORC2. By far, the researches about the relationship between mTORC1 signaling pathway and tumors have been attached greater importance to than mTORC2 signaling pathway. In recent years,several studies found that rnTORC2 signaling pathway is involed in the regulation of epithelial sodium channel.

关 键 词：哺乳动物雷帕霉素靶蛋白 上皮细胞钠通道 信号通路 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]