昆明-无毛小鼠生物学特性的研究  

Biological characteristic of Kunming-hairless mice

作　　者：沈秀[1] 刘晓秋[1] 周则卫[1] 杨福军[1] 张晓东[1] 龙伟[1] 王浩[1] 洪阁[1] 徐文清[1] 

机构地区：[1]中国医学科学院放射医学研究所,天津市分子核医学重点实验室,天津300192

出　　处：《国际放射医学核医学杂志》2013年第2期74-76,87,共4页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：天津市科技发展计划项目（05YFGPGX07200）

摘　　要：目的观察新品系昆明-无毛小鼠在正常、照射及接种肿瘤情况下的生物学指标。方法①测定正常昆明小鼠和正常昆明．无毛小鼠的各项生理指标；②将昆明小鼠和昆明-无毛小鼠同时接种上肿瘤（肝癌H22、白血病L1210），观察其生长情况；③昆明小鼠和昆明．无毛小鼠接受·37Cs源1射线照射后，观察白细胞、胸腺系数、脾系数等各项生理指标。结果昆明小鼠与昆明-无毛小鼠正常指标之间无显著差异，只是昆明-无毛小鼠的胸腺略小一些；昆明-无毛小鼠和昆明小鼠接种上两种肿瘤后，肿瘤生长情况均较好；昆明小鼠和昆明．无毛小鼠接受”Cs源γ射线照射后，白细胞计数、胸腺系数、脾系数等各项生理指标均明显下降。结论作为纯系小鼠的昆明．无毛小鼠具备昆明小鼠的生物学特性，可应用于科学实验研究。Objective To observe the biological parameters of the new strain Kunming-hairless mice on the condition of normal, irradiation and tumor-implanting. Methods ①The physiological parameters of normal Kunming mice and normal Kunming-hairless mice were observed. ②After being inoculated with hepatic carcinoma H22, leukemia L1210, tumor growth of the two kinds of mice was observed. ③White blood cell count, thymus index and spleen index parameters were observed after irradiation by 137Cs γ-ray. Results The differences of normal parameters between Kunming mice and Kunming-hairless mice were not significant, but the immune parameter-thymuses of Kunming-hairless mice were smaller than that of Kunming mice, tumors growth after implantation were quite well in both strain Kunming and Kunming-hairless mice. Conclusion As pure strain animal, Kunming-hairless mice possesses biological traits of Kunming mice, it can be applied to the sciences experiment.

关 键 词：肝肿瘤 实验性 白血病L1210 昆明-无毛小鼠 昆明小鼠 

分 类 号：R285.5[医药卫生—中药学]