沙颍河水邻苯二甲酸酯污染对儿童甲状腺功能及智力的影响  

Influence of phthalates from Shaying river on children's intelligence and secretion of thyroid hormone

作　　者：李桉琪[1] 唐春宇[2] 黄辉[2] 程学敏[2] 高亚琳[1] 陈虹钖 黄祺[1] 罗毅鑫[1] 薛玉堂[3] 左其亭[4] 巴月[2] 崔留欣 

机构地区：[1]郑州大学临床医学系,郑州450001 [2]郑州大学公共卫生学院环境卫生学教研室 [3]沈丘县疾病预防控制中心 [4]郑州大学水利与环境学院

出　　处：《卫生研究》2013年第2期236-240,共5页Journal of Hygiene Research

基　　金：国家重大水专项子课题(No.2009ZX07210-006-3-3);全国大学生创新创业训练计划项目(No.121045961)

摘　　要：目的探索淮河流域沙颍河水邻苯二甲酸酯类物质(PAEs)污染现状及其对儿童智力发育和甲状腺相关激素的影响。方法在沙颍河出河南省的S县段内,分别距河床2km以内和20km以外,各选取1个村庄作为污染区和对照区,分别采集河水和居民生活饮用水。高效液相色谱法检测河水和饮用水水中4种PAEs(DEP、DBP、DMP、DEHP)水平;整群抽取两区8～13岁在校学生作为观察对象进行问卷调查;采用联合型瑞文测验方法对两区学生进行智力测验,化学发光法测定促甲状腺激素(TSH)、游离三碘甲腺原氨酸(FT3)和游离四碘甲腺原氨酸(FT4)含量。结果沙颍河S段各断面DEP、DBP水平均超过国家地表水环境质量标准;同对照区相比,污染区饮用水中DEP、DBP均明显高于对照区,差异有统计学意义(P<0.05)。污染区儿童血清中FT4明显高于对照区儿童(P<0.05)。污染区儿童智力低于对照区儿童(P<0.05)。结论污染区儿童体内甲状腺相关激素及智力发育受到一定影响,是否与水质PAEs污染有关,尚需进一步调查。Objective To investigate the effeet of phthalates exposure from drinking water on children＇ s intelligence and secretion of thyroid hormone. Methods Two villages in S County were selected randomly as polluted area and control area according to the distanee from the Shaying river basin. Phthalates including DEP, DBP, DMP, DEHP were measured both in the river water and drinking water using HPLC method. Children aged 8 to 13 years old studying in the village primary school were recruited by cluster sampling （n = 154）. The combined Reven Test was used to test children intelligence and ELISA method was used to determined thyroid hormone levels. Results Theconcentrations of phthalates （DEP, DBP） were exceeding standards of surface water quality in any of the three sections of the river. Compared to the control area, the concentration of DEP and DBP in drinking water were significant higher in the polluted area than that in control area （ P 〈 0.05 ）. Children from polluted area had significant higher FT4 concentration compared to children from control area （P 〈 0. 05 ）. Intelligence level in children from polluted area was lower than that from control area （P 〈 0. 05 ）. Conclusion The drinking water has been polluted by Shaying fiver and thyroid hormones levels of children were affected in the polluted areas. It is necessary to verify if this change is related to the phthalates.

关 键 词：邻苯二甲酸酯 甲状腺激素 智力 儿童 

分 类 号：R123.5[医药卫生—环境卫生学] R581[医药卫生—公共卫生与预防医学]