芪参复康胶囊治疗首发轻中度抑郁症患者事件相关电位的变化  

A prospective study of event-related potentials in patients with first-episode mild-and-moderate depressions treated with Qishen Fukang Capsules

作　　者：陈玖[1] 杨来启[1] 李新田[1] 林昱[1] 徐樊[1] 付清海[1] 张彦[1] 

机构地区：[1]解放军第三医院全军精神疾病防治中心,陕西省宝鸡721004

出　　处：《中华全科医师杂志》2013年第4期296-298,共3页Chinese Journal of General Practitioners

基　　金：基金项目：军队中医药科研专项课题（10ZYX108）

摘　　要：对72例首发轻中度抑郁症患者给予芪参复康胶囊治疗，观察治疗前和治疗6、12和24周时事件相关电位P3的变化，并以70例健康志愿者为对照。与治疗前比，抑郁患者治疗后汉密尔顿抑郁量表总分均值降低[（29．1±5．1）分与（10．4±4．1）分]，P3潜伏期缩短、波幅升高（P〈0．01），治疗6周与治疗前潜伏期、波幅的差值较治疗12周与治疗6周差值显著偏大（P〈0．01）。提示首发轻中度抑郁症患者用芪参复康胶囊长期治疗后临床症状明显缓解，疗效肯定，脑诱发电位指标改善。A total of 72 patients with first-episode mild-and-moderate depression took Qishen Fukang Capsules. The change of event-related potential P3 was determined before and after treatment for 6, 12 and 24 weeks. And another 70 healthy controls received the same tests simultaneously. Compared with before treatment, HAMD scores after treatment were lower in the patient group [ （ 29. 1 ± 5.1 ） score vs. （ 10.4 ± 4. 1 ） score]. P3 latencies were shorter and amplitudes became higher after treatment （ P 〈 0. 01 ）. And the difference of before and after treatment for 6 weeks was larger than the difference of 12 weeks and after treatment for 6 weeks （ P 〈 0. 01 ）. The curative effect is definite. And the clinical symptoms and brain evoked potential index have improved in patients with first-episode mild-and-moderate depression after medication.

关 键 词：芪参复康胶囊 事件相关电位 

分 类 号：R285.5[医药卫生—中药学]