慢性心房颤动患者左心房扩大与左心房血栓形成的相关性  

Correlation between left atrial enlargement and left atrial thrombosis in patients with chronic atrial fibrillation

作　　者：陈简庆 谭伟硕 吴伟军 

机构地区：[1]广东省恩平市人民医院心内科,广东恩平529400

出　　处：《心血管康复医学杂志》2013年第2期135-137,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨慢性心房颤动患者左心房扩大与左心房血栓形成的相关性。方法:选择我院确诊的80例慢性心房颤动伴左心房扩大患者为左心房扩大组,80例慢性心房颤动左心房无扩大患者为心房无扩大组,应用经食管超声检测左心房大小及观察有无血栓。根据食管超声检查结果分为血栓形成组(22例)和无血栓组(138例),通过单因素及多元逐步Logistic回归分析,分析左心房血栓形成的危险因素。结果:超声心动图显示左心房扩大组心房内血栓形成率明显高于左心房无扩大组(17.5%比10.0%,P<0.05)。多因素Logistic回归分析显示,与心房内血栓形成的相关的危险因素有:左心房直径(OR=4.514,95%CI:1.243～14.206,P=0.01)、病程(OR=1.106,95%CI:0.898～1.071,P=0.035)。结论:心房颤动患者的左心房扩大,可导致心肌收缩力下降,增加左心房内血栓形成的危险性,是左心房内血栓形成的有意义的预测因子。Objective：To investigate correlation between left atrial enlargement （LAE） and left atrial thrombosis in pa- tients with chronic atrial fibrillation （CAF）. Methods：A total of 80 CAF patients with LAE diagnosed in our hospital were enrolled as LAE group,another 80 CAF patients without LAE were regard as no-LAE group. Transesophageal echocardiography was used to measure left atrial size and observe whether there＇s thrombus. According to results of transesophageal echocardiography,patients were divided into thrombosis group （n = 22） and no-thrombosis group （n = 138）. Single factor and multivariate gradual Logistic regression analysis were used to analyze risk factors for left atrial thrombosis. Results： Echocardiography indicated that atrial thrombosis rate in LAE group was significantly higher than that of no-LAE group （17.5% vs. 10.0%, P〈0.05）. Multivariate Logistic regression analysis indicated that risk factors related with atrial thrombosis were left atrial diameter （OR = 4. 514,95% CI：1. 243 - 14. 206, P = 0.01） and course of disease （OR = 1. 106,95%CI：0. 898- 1. 071, P = 0. 035）. Conclusion：The left atrial enlargement may lead to myocardial contractility decrease and increase risk of left atrial thrombosis so left atrial enlargement is a meaningful predictor for left atrial thrombosis in patients with chronic atrial fibrillation.

关 键 词：心房颤动 心脏扩大 血栓形成 

分 类 号：R541.75[医药卫生—心血管疾病]