华法林预防心房颤动患者发生脑梗塞的临床意义  

Clinical significance of warfarin on prevention of brain infarction in patients with atrial fibrillation

作　　者：李志华[1] 罗晓菡[1] 卢英民[1] 姚能才[1] 黄达民[1] 张金春[1] 宋蕾[1] 韦彩雯[1] 

机构地区：[1]上海交通大学医学院附属新华医院(崇明)心内科,上海崇明县202150

出　　处：《心血管康复医学杂志》2013年第2期166-168,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:通过比较华法林与拜阿司匹林对非瓣膜性心房颤动(NVAF)的疗效及安全性,以明确NVAF患者抗栓治疗的最佳选择。方法:根据国际指南中关于NVAF血栓栓塞危险因素的建议,入选120例NVAF患者,随机均分为华法林组(目标INR 2～3)与阿司匹林(100mg/d)组,比较两组脑梗塞和出血事件的发生率。结果:华法林组脑梗塞发生率明显低于阿司匹林组(1.67%比8.33%,P<0.05)。华法林组7例(11.67%),阿司匹林组6例(10.00%)发生出血,华法林组出血发生率高于阿司匹林组,但差异无显著性(P>0.05),两组均无严重岀血情况。结论:华法林抗凝效果明显,可以安全、有效地减少和防止脑梗塞发生。Objective： To compare curative effect and safety between warfarin and aspirin in patients with non-valvu- lar atrial fibrillation （NVAF）, in order to determine the optimal choice of antithrombotic therapy for NVAF pa- tients. Methods： According to recommendations of international guidelines on risk factors of NVAF thromboembo- lism, a total of 120 NVAF patients were enrolled, and randomly and equally divided into warfarin group [target international normalized ratio （INR） 2- 3] and aspirin group （100mg/d）. Incidence rates of brain infarction and bleeding events were compared between two groups. Results： Incidence rate of brain infarction in warfarin group was significantly lower than that of aspirin group （1.67% vs. 8.33%, P〈0.05） Incidence rate of bleeding （11.67%, 7/60） in warfarin group was higher than that of aspirin group （10.00%, 6/60）, but no significant difference （P〉0.05）. There was no severe bleeding event in both groups. Conclusion： Anticoagulation effect of Warfarin is obvious, which can safely, effectively reduce and prevent brain infarction.

关 键 词：华法林 阿司匹林 心房颤动 脑梗塞 

分 类 号：R541.75[医药卫生—心血管疾病]