慢性阻塞性肺疾病急性加重时血清和痰液中SP-D的变化和临床意义  

Changes and clinical significance of SP-D in Sputum and Serum of acute exacerbation of chronic obstructive pulmonary disease

作　　者：刘双林 沈奕播 李琦 王长征 

机构地区：[1]第三医大学新桥医院呼吸内科,重庆400037

出　　处：《中华肺部疾病杂志（电子版）》2013年第2期26-29,共4页Chinese Journal of Lung Diseases(Electronic Edition)

摘　　要：目的通过测定慢性阻塞性肺疾病(COPD)急性加重期(AECOPD)、稳定期患者的血清和诱导痰中肺表面活性蛋白D(SP-D)的变化,探讨痰和血清SP-D在AECOPD中的临床意义。方法随机选择我院呼吸内科住院及门诊COPD患者共50例,其中24例AECOPD患者、26例COPD稳定期患者。同时随机抽送14例吸烟非COPD和16例不吸烟者作为对照。收集患者及对照组临床资料、血清和诱导痰标本,用ELISA法测定血清及诱导痰中肺表面活性蛋白D(SP-D)水平。结果 AECOPD患者血清SP-D水平显著高于稳定期COPD和非COPD对照组(P<0.05),而痰SP-D水平则与血清水平相反,AECOPD组显著低于稳定期及对照组(P<0.05),AECOPD组血清SP-D水平与痰SP-D水平呈显著负相关性(R=-0.705,P<0.001)。结论痰SP-D水平与血清水平有较好的相关性,监测痰SP-D水平可替代血清监测作为COPD的参考生物学标志物。Objective Through measuring the level of SP-D in serum and induced sputum between the patients with acute exacerbation of chronic obstructive pulmonary disease （ AECOPD ）, chronic obstructive pulmonary disease （COPD） in the stable phrase and healthy controls, to explore the clinical significance of SP-D in induced sputum and serum in the patients of AECOPD. Method 50 patients with COPD were randomly chosed from our respiratory medicine. They included 24 patients with AECOPD, 26 patients with stable COPD. 14 healthy smokers and 16 healthy nonsmokers were recruited as the control group. The clinical data, serum and induced sputum samples were collected from all the subjects. Results The SP-D was measured by ELISA. The level of the SP-D in serum of patients with AECOPD was significantly higher than the stable COPD and the control group （P 〈 0.05）. On the contrary, the concentration of sputum SP-D in AECOPD was significantly lower than the stable COPD and the control group （ P 〈 0.05 ）. Moreover, the levels of SP-D in sputum are significant negative correlation with it in serum of patients with AECOPD （R = 0. 705, P〈0.001 ）. Conclusion SP-D in sputum has good correlation with it in plasma, monitoring the level of SP-D in sputum may take the place of plasma as a biological markers of AECOPD.

关 键 词：肺疾病 慢性阻塞性 肺表面活性蛋白D 诱导痰 

分 类 号：R563[医药卫生—呼吸系统]