联合检测血浆和肽素与肌钙蛋白在急性心肌梗死诊断中的应用  

Accomplication of joint detection of copeptin and cTnI in early diagnosis for patients with acute myocardial infarction

作　　者：魏晓霞[1] 肖传实[1] 李虹[1] 张慧萍[1] 马霞[1] 李俊男[1] 卢彩兰[1] 李燕[1] 

机构地区：[1]山西医科大学第二医院,山西太原030001

出　　处：《临床医药实践》2013年第4期243-245,共3页Proceeding of Clinical Medicine

基　　金：山西省高等学校科技创新项目资助(项目编号:20101142)

摘　　要：目的:观察急性胸痛患者血浆和肽素(Copeptin)与肌钙蛋白(cTnI)水平的变化,寻找早期快速诊断急性心肌梗死(AMI)的方法。方法:收集急诊科2010年11月—2012年5月就诊的100例发病6h内的急性胸痛患者,其中AMI者48例,不稳定心绞痛32例,非心源性胸痛20例,进行血浆Copeptin及cTnI的定量测定。结果:AMI组血浆Copeptin水平较其他两组明显升高,差异有统计学意义(P<0.05),cTnI阴性AMI患者血浆Copeptin水平明显高于cTnI阳性AMI患者。结论:AMI患者早期Copeptin水平明显升高,血浆cTnI浓度变化与Copeptin水平呈负相关,故联合检测血浆和肽素与肌钙蛋白,有助于急诊科胸痛的排查,提高AMI早期诊断率。Objective ：To observe the changes of eopeptin and cardiac treponin I（cTnI） in plasma for patients with acute chest pain,inorder to find the way in early diagnosis for patients with acute myocardial infarction（AMI）. Methods：A total of 100 acute chest pain patients occurred early（within 6 hours） admitted to the hospital emergency from Novermber 2010 to May 2012 were collected ,include 48 cases of AMI, 32 cases unstable angina ,non-cardiac chest pain 20 cases ,copeptin and cTnI in plasma were tested. Results：patients with AMI copeptin levels increased significantly compared with anyone group（P〈0.05）,the level of copeptin in cTnI-negative AMI group was obviously higher than cTnI-positive AMI group. Conclusion：The level of eopeptin in patients with early AMI have been significantly high; the concentration changes between copeptin and cTnI in plasma is negative correlation ;copeptin joint cTnI can be used as early diagnostic indicator of AMI,and can increase the rate of diagnosis of AMI.

关 键 词：和肽素 肌钙蛋白 急性心肌梗死 

分 类 号：R542.22[医药卫生—心血管疾病]