血清降钙素原及超敏C-反应蛋白在急性发热患者诊断中的应用  

Application of Serum Procalcitonin and High Sensitive C-reactive Protein in Diagnosing Fever Patients

作　　者：徐志锋[1] 余梅娟[1] 李志全[1] 陈荣健[1] 李国明[1] 

机构地区：[1]广东省江门市中心医院急诊科,广东江门529071

出　　处：《河北医学》2013年第5期669-672,共4页Hebei Medicine

摘　　要：目的:探讨血清降钙素原(Procalcitonin,PCT)与超敏C-反应蛋白(hs-CRP)检测在急性发热疾病病因学的诊断价值。方法:将我院120例发热待查患者做为研究对象,检测血清PCT和hs-CRP水平,并进行病原学检查确诊。评价PCT和hs-CRP对急性发热疾病病因学的诊断价值。结果:细菌感染组患者血清PCT和hs-CRP水平均显著高于非细菌感染组(P<0.05);PCT诊断细菌感染的敏感性、特异性、阳性预测值及阴性预测值分别为89.5%、82.4%、92.8%和75.7%,hs-CRP诊断细菌感染的敏感性、特异性、阳性预测值及阴性预测值分别为84.9%、58.8%、83.9%和60.0%。结论:细菌感染所致的急性发热患者血清PCT和hs-CRP水平显著升高,二者检测可用于急性发热患者的病因学诊断,PCT敏感性及特异性更好。Objective： To explore the etiologic diagnostic value of procalcitonin （PCT） and high sensitive e-reactive protein （ hs-CRP） in diagnosis of fever patients. Method： 120 fever patients were selected as research subjects. Serum PCT and hs-CRP were detected and pathogenic examination were made to identify the disease. The diagnostic value of PCT and hs-CRP were evaluated. Result： Serum PCT and hs-CRP in bacteria infection patients were much higher than that of non-bacterial infection patients （ P〈0.05 ） ; The sensitivity, speeificityI positive predictive value and negative predictive value of PCT were 89.5%, 82.4%, 92.8% and 75.7% respectively, of which for hs-CRP were 84.9%, 58.8%, 83.9% and 60.0% respectively. Conclusion： Serum PCT and hs-CRP in the fever patients caused by bacteria infection greatly in- crease. The detection of PCT and hs-CRP can be used for etiologic diagnosis of fever patients. The sensitivity and speeificity of PCT are better than hs-CRP.

关 键 词：发热 病因学诊断 降钙素原 超敏C-反应蛋白 

分 类 号：R446.6[医药卫生—诊断学]