哺乳动物促性腺激素抑制激素的生殖内分泌调节与行为作用  

Gonadotropin-inhibitory hormone in regulation of reproduction and behavior in mammalians

作　　者：孟凡森[1] 陈学群[1] 杜继曾[1] 

机构地区：[1]浙江大学医学院基础医学系,浙江杭州310058

出　　处：《浙江大学学报（医学版）》2013年第2期224-231,共8页Journal of Zhejiang University(Medical Sciences)

基　　金：国家重点基础研究发展计划资助项目(2012CB518200)

摘　　要：哺乳动物中促性腺激素抑制激素(gonadotropin-inhibitory hormone,GnIH)同源物(RF-amide related peptide,RFRP)的神经元胞体主要存在于下丘脑背内侧核(dorsomedial hypothalamicnucleus,DMH),其神经纤维主要投射到视前区(preoptic area,POA)和下丘脑正中隆起,其受体主要分布在下丘脑。RFRP神经元投射到促性腺激素释放激素(gonadotropin-releasing hormone,GnRH)神经元上;最终,RFRP和GnRH共同完成哺乳动物生殖轴功能调节。RF-amide related peptide （RFRP） is the orthologue of gonadtropin-inhibitory hormone （GnlH） in mammals. The bodies of RFRP cell are located in the dorsomedial nucleus of the hypothalamus （DMH） and the fibers project to preoptic area （POA） and median eminence of the hypothalamus. Its receptor mainly distributes in hypothalamus. RFRP fibers .project to GnRH cells to regulate mammalian reproduction axis. This paper reviews the progress of current researches on RFRP in regulation of animal behaviors, including reproduction, food intake, anxiety and stress response.

关 键 词：促性腺激素抑制激素 促性腺激素释放激素 生殖 应激 摄食 

分 类 号：R339.2[医药卫生—人体生理学]