神经浸润胰腺癌中GDNF和COX-2表达的相关性  

Association of GDNF and COS-2 in Pancreatic Carcinoma with Peri- neural Incasion

作　　者：曹如波[1] 丁乾[1] 薛军[1] 黄晶[1] 彭纲[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院肿瘤中心,武汉市430023

出　　处：《医学分子生物学杂志》2012年第5期377-379,共3页Journal of Medical Molecular Biology

摘　　要：目的研究神经浸润胰腺癌中GDNF和COX-2表达的相关性。方法采用免疫组织化学检测65例胰腺癌组织中GDNF、COX-2表达，S-100标记神经纤维束膜，分析胰腺癌中GDNF和COX-2表达的相关性。结果有神经浸润胰腺癌组和无神经浸润胰腺癌组GDNF、COX-2阳性率均显著高于正常胰腺组（P〈0．05），有神经神经浸润胰腺癌组GDNF、COX-2阳性率显著高于无神经浸润胰腺癌组（P〈0．05）。有神经浸润胰腺癌组织中将GDNF及COX-2表达行相关性研究，GDNF与COX-2表达呈正相关（t=0．762，P=0．006）。结论GDNF、COX-2在胰腺癌中的表达与神经浸润密切相关，在胰腺癌神经浸润过程中具有协同作用。Objective To investigate the association of GDNF and COX-2 expression in pan- creatic carcinoma with perineural invasion metastasis. Methods Immunohistochemistry were used to detect the expression of GDNF and COX-2, S-100 staining were conducted to mark the membrane of nerve fiber bundle, and the relevance of GDNF and COX-2 expression in pancreatic carcinoma were analyzed. Results The positivity rates of GDNF and COX-2 expression were significantly higher in pancreatic carcinoma tissue （with or without perineural invasion） than in normal pancreatic tissue （P 〈 0.05 ） , the positivity rates of GDNF and COX-2 expression were significantly higher in pan- creatic carcinoma tissue with perineural invasion than in those without perineural invasion （P 〈 0.05） , There was a positive correlation between GDNF and COX-2 expression in pancreatic carci- noma tissue with perineural invasion （ rs = 0. 762, P = 0. 006） . Conclusion The expression of GDNF and COX-2 in pancreatic carcinoma may be closely related to perineural invasion, and they may have synergistic effect on the process of perineural invasion in pancreatic carcinoma.

关 键 词：胰腺癌 神经浸润 GDNF COX-2 

分 类 号：R349.7[医药卫生—基础医学]