左西孟旦对慢性心力衰竭心室收缩同步性的影响  

Effect of levosimendan on ventricular systolic synchronicityin chronic heart failure

作　　者：郭拥军[1] 张登庆[1] 葛艳[1] 吴荣[1] 谢强[1] 李卫华[1] 

机构地区：[1]厦门大学附属第一医院心内科/心超室厦门市心血管病研究所,厦门361003

出　　处：《临床心血管病杂志》2013年第4期254-256,共3页Journal of Clinical Cardiology

摘　　要：目的:评价左西孟旦对慢性心力衰竭(心衰)患者心室收缩同步性的影响。方法:选取慢性心衰患者38例,随机分成常规治疗组和左西孟旦组,每组19例。随访12周,观察两组用药前后呼吸困难程度、脑利钠肽(BNP)水平、心室收缩同步性及左室射血分数(LVEF)的变化。结果:用药后4周,与治疗前相比,左西孟旦能显著改善呼吸困难程度[呼吸困难评分(3.16±1.17)∶(1.54±1.03),P<0.05],降低BNP水平[(3 124.52±291.37)ng/dl∶(1 867.26±204.82)ng/dl,P<0.01]、改善心室收缩同步性[ΔTs(135.22±34.47)ms∶(90.86±26.19)ms,P<0.05]和提高LVEF[(0.25±0.04)∶(0.31±0.06),P<0.05],且与常规治疗组相比,4个指标均具有统计学意义的改善(P<0.05)。结论:左西孟旦可降低慢性心衰患者BNP水平,改善心室收缩同步性,提高LVEF。Objective：To evaluate the effect of levosimendan on ventricular systolic synchronicity（VSS） in patients with chronic heart failure（CHF）. Method：A randomized,open,control clinical trial was conducted in 38 patients with CHF,whose left ventricular eject fraction（LVEF） was ≤30% and with VSS.Nineteen of them were randomanzed to regular treatment group,and the other 19 were treated with levosimendan beside regular treatment in levosimendan group.Dyspnea,BNP level,VSS,LVEF before and after drug administration were observed. Result：On the end of 4th week,there were significant differences in the improvement of dyspnea [（3.16±1.17） vs（1.54±1.03）,P0.05],decrease of BNP [（3 124.52±291.37）ng/dl vs（1 867.26±204.82）ng/dl,P0.01],increase of VSS [ΔTs（135.22±34.47）ms vs（90.86±26.19）ms,P0.05] and LVEF [（0.25±0.04） vs（0.31±0.06）,P0.05] before and after the treatment of Levosimendan.In addition,compared with regular treatment group,there were significant differences of the 4 parameters in levosimendan group（P0.05）. Conclusion：Levosimendan can decrease BNP level,improve VSS and increase LVEF in patients with CHF.

关 键 词：充血性心力衰竭 左西孟旦 心室收缩同步性 脑利钠肽 左室射血分数 

分 类 号：R541.5[医药卫生—心血管疾病]