诱导性多能干细胞免疫原性的发生机制与干预对策  

Mechanisms on Immunogenicity of Induced Pluripotent Stem Cells and Interferring Strategies

作　　者：王娅婕[1] 郝莎[1] 袁卫平[1] 程涛[1] 

机构地区：[1]中国医学科学院,北京协和医学院血液学研究所,血液病医院实验血液学国家重点实验室,天津300020

出　　处：《中国细胞生物学学报》2013年第4期410-416,共7页Chinese Journal of Cell Biology

基　　金：国家医药重大专项(批准号:2011ZX09102-010-04);国家重点基础研究发展计划(973)项目(批准号:2010CB945204;2012CB966600);科技部国际合作计划(批准号:2010DFB30270)资助的课题~~

摘　　要：诱导性多能干细胞(iPSC)技术为再生医学开辟了一条广阔而富有前景的新途径。但近期对于自体来源的iPSC及其分化细胞免疫原性的研究结果存在争议,因此研究影响iPSC免疫原性的因素、机体对其可能的免疫排斥及相关免疫耐受机制是未来实现iPSC成功临床应用的重要基础课题。该文将就诱导性多能干细胞的免疫原性相关研究进展作一综述。Induced pluripotent stem cells （iPSC） hold the great promise for dealing with a wide range of genetic and acquired diseases in regenerative medicine. However, to reveal the full potential of iPSC, many ob-stacles must be overcome, lmmunogenicity of iPSC appears to be an important and controversial issue surrounding potential therapeutic applications of iPSC. In the current review, we discuss the mechanisms that contribute to the immunogenicity of iPSC and iPSC-derived cells, and highlight the potential strategies for successful engraftment of iPSC-derived cells in the recipients.

关 键 词：诱导性多能干细胞(iPSC) 免疫原性 免疫耐受 再生医学 

分 类 号：R392[医药卫生—免疫学]