rt-PA静脉溶栓联合复方樟柳碱治疗视网膜中央动脉阻塞的疗效观察  

Therapeutic effect of rt-PA combined with compound anisodine injection on central retinal artery occlusion

作　　者：吴小军[1] 高丰[1] 赵青[1] 周媛媛[1] 

机构地区：[1]湖北医药学院附属襄阳医院,湖北省襄阳市441000

出　　处：《眼科新进展》2013年第4期369-372,共4页Recent Advances in Ophthalmology

摘　　要：目的观察重组组织型纤溶酶原激活剂(recombinant tissue plasminogen activator,rt-PA)联合复方樟柳碱注射液治疗视网膜中央动脉阻塞(central retinal artery occlusion,CRAO)的临床疗效及安全性。方法 48例(48眼)CRAO患者随机分为治疗组(24例)和对照组(24例)。对照组采用硝酸甘油、醋甲唑胺、葛根素和复方樟柳碱治疗,同时给予吸氧、按摩等常规治疗;治疗组在常规治疗的同时,另给予rt-PA静脉溶栓治疗,观察两组视力、眼底、视野改变。结果治疗组治疗后视力明显好于对照组,差异有统计学意义(P<0·05)。对照组总有效率为70.8%,治疗组为91.7%,差异有统计学意义(P<0.05)。对照组治疗后视野缺损约(74.26±12·91)%,治疗组为(35.08±16.33)%,差异有统计学意义(P<0.05)。治疗组治疗前血液中纤维蛋白原含量为(3.62±0.65)g·L-1,治疗后为(2.33±0.29)g·L-1,治疗前后差异有显著统计学意义(P<0.01);对照组治疗前血液中纤维蛋白原含量为(3.94±0.72)g·L-1,治疗后为(3.73±0.59)g·L-1,差异无统计学意义(P>0.05);两组治疗前纤维蛋白原含量差异无统计学意义(P>0.05),治疗后差异有显著统计学意义(P<0.01)。结论 rt-PA静脉溶栓联合复方樟柳碱治疗是安全有效的能显著改善患者的预后。Objective To observe the clinical effect and its safety of recombinant tissue plasminogen activator（rt-PA）combined with compound anisodine injection on treatment of central retinal artery occlusion（CRAO）.Methods A total of 48 patients（48 eyes） with CRAO were randomly divided into treatment group（24 cases）and control group（24 cases）.The control group was treated by nitroglycerin,methazolamide,puerarin and compound anisodine,and also oxygen,massage and other conventional therapy.The treatment group also received conventional therapy as control group,and was given intravenous thrombolysis with rt-PA.The vision,fundus and visual field changes were observed.Results The vision in treatment group was obviously better than that of control group after treatment,and there was significant difference（P0.05）.The effective rate of control group was 70.8%,while treatment group was 91.7%,and there was significant difference between the two groups（P0.05）.The visual field defect in control group was about（74.26±12.91）%,while treatment group was（35.08±16.33）%,and there was a significant difference（P0.05）.The profibrin in blood was（3.62±0.65）g·L-1 before treatment,and（2.33±0.29）g·L-1 after treatment in treatment group,and there was a significant difference（P0.01）.The profibrin in blood was（3.94±0.72）g·L-1 before treatment,and（3.73±0.59）g·L-1 after treatment in control group,and there was no significant difference（P0.05）.There was no significant difference before treatment between the two groups（P0.05）,but there was a significant difference after treatment between the two groups（P0.01）.Conclusion Rt-PA combined with compound anisodine injection treating on central retinal artery occlusion is effective and safe,and can improve the prognosis.

关 键 词：重组组织型纤溶酶原激活剂 复方樟柳碱 静脉溶栓 视网膜中央动脉阻塞 

分 类 号：R654.2[医药卫生—外科学]