胃肠道Cajal间质细胞与干细胞因子/c-kit信号系统的研究进展  

Progress in research on ICCs in gastrointestinal tract and SCF/c-kit signal system

作　　者：田姣[1] 王宝西[1] 江逊[1] 

机构地区：[1]第四军医大学唐都医院儿科,陕西西安710038

出　　处：《临床儿科杂志》2013年第4期385-388,共4页Journal of Clinical Pediatrics

基　　金：国家自然科学基金资助项目(No.81170331)

摘　　要：胃肠道Cajal间质细胞(interstitial cells of Cajal,ICCs)是一类分布于消化道各个部位的特殊间质细胞,它和肠神经系统、平滑肌之间的特殊位置关系构成了"肠神经-ICCs-平滑肌细胞"的网络结构,其中ICCs是该网络重要的协调者,与肠道慢波的形成密切相关。胃肠道ICCs的特异性受体c-kit,与其配体干细胞因子(stem cell factors,SCF)结合后启动的信号途径,在ICCs的生长、发育及表型维持中起着重要作用。因此,从SCF/c-kit信号系统入手,有望拉开治疗ICCs相关性胃肠运动功能障碍性疾病的新序幕。Gastrointestinal interstitial cells of Cajal （ICCs）, distributed throughout the whole gastrointestinal （GI） tract, are a special kind of mesenchymal cells. The special relationship among ICCs, enteric nervous system and smooth muscle con- tributes to the formation of the ＂neuron-ICC-smooth muscle＂ networks. Especially, ICC is the important coordinator in the net- work, and is closely related with the generation of intestinal slow waves. There is the signaling pathway which is activated by c- kit, a specific membrane receptor of ICC, binds to stem cell factor （SCF）, a ligand for c-kit, and the pathway plays an important role in the development and maintenance of ICC. Therefore, through the investigation of the SCF/c-kit signaling pathway, it is expected to find a new therapy for ICCs associated gastrointestinal motility disorders.

关 键 词：CAJAL间质细胞 干细胞因子 c—kit 胃肠动力障碍性疾病 

分 类 号：R333[医药卫生—人体生理学]