经股动脉途径射频消融术建立beagle犬永久性房室传导阻滞模型  

Establishment of complete atrioventricular block model in Beagle dog

作　　者：信鹏程[1] 陈一和[1] 李岳春[1] 李进[1] 张文武[1] 林加锋[1] 

机构地区：[1]温州医学院附属第二医院心内科,325027

出　　处：《浙江医学》2013年第5期330-333,340,共5页Zhejiang Medical Journal

基　　金：国家自然科学基金资助项目（81070155）

摘　　要：目的探讨经股动脉途径射频消融术建立beagle犬永久性房室传导阻滞模型的可行性，并比较其与传统造模方法的利弊。方法将12只beagle犬分成两组，预置起搏器后，左心室消融组（6只）经股动脉途径于主动脉窦下左心室间隔上部消融建立房室传导阻滞模型，右心窒消融组（6只）经股静脉途径于koch三角处消融建立房室传导阻滞模型。两组以建立完全房室传导阻滞为终点。术后随访4周后处死动物．比较造模成功率、手术并发症及模型稳定性。结果左心室消融组成功率大于右心室消融组，术中并发症小于右心室消融组，左心室消融组手术时间及X线曝光时间短于右心室消融组（均P〈0．05），两组模型稳定性差异无统计学意义（均P〉0．05）。结论经股动脉途径射频消融术建立beagle犬永久性房室传导阻滞模型较传统途径消融法成功率高且并发症少，在有条件的实验室和有经验的单位，可优先选用经股动脉射频消融术建立房室传导阻滞模型。Objective To establish a animal model of complete atrioventricular block （AVB） model. Methods After pacemaker implanted in 12 Beagle dogs, AVB was induced by interrupting His bundle conduction by radiofrequency ablation at the base of the aortic cusp from femoral artery in left ventricular ablation group （n=6） and at the Koch triangle from femoral vein in right ventricular ablation group 0~=6）. Animals were sacrificed 4 weeks after AVB was induced, then the pathological changes of myocardium were examined; and the success rate, complications and stability of model were compared between two groups. Results The success rate was higher, intraoperative complications were less, the time of operation and X-ray exposure was shorter in left ventricular ablation group than those in right ventricle ablation group （all P〈0.05）. Conclusion A-V block model has been successfully established with radiofrequency ablation from femoral artery in Beagle dogs with high success rate and low complications.

关 键 词：房室传导阻滞 射频消融 BEAGLE犬 疾病模型 

分 类 号：R971[医药卫生—药品]