一种高密度基因芯片的优化方法  

A method of high-density gene chip optimization

作　　者：孙啸[1] 何农跃[1] 赵雨杰[1] 陆祖宏[1] 

机构地区：[1]东南大学生物科学与医学工程系分子与生物分子电子学实验室,江苏南京210096

出　　处：《生物技术》2000年第4期42-46,共5页Biotechnology

基　　金：国家自然科学基金资助课题!(6 99710 10 )

摘　　要：Gene chip is the fusion of molecular biology,microelectronics and micromechanics.Mask board is the key to high-density gene chip fabrication.By using masks ,DNA probes can be synthesized in situ with high density and accurate location.But it is costly to make the masks.A method of chip optimization is proposed to reduce the number of masks needed for gene chip synthesis,to reduce the synthesiscycles,and then to increase the efficiency of chip making.It is very important to gene chip applications.Gene chip is the fusion of molecular biology,microelectronics and micromechanics.Mask board is the key to high-density gene chip fabrication.By using masks ,DNA probes can be synthesized in situ with high density and accurate location.But it is costly to make the masks.A method of chip optimization is proposed to reduce the number of masks needed for gene chip synthesis,to reduce the synthesiscycles,and then to increase the efficiency of chip making.It is very important to gene chip applications.

关 键 词：基因芯片 优化技术 高密度基因芯片 

分 类 号：Q503[生物学—生物化学] TV4[水利工程—水工结构工程]