临床病原菌种类及耐药性监测  

THE MONITORING OF KINDS AND BACTERIAL RESISTANCE OF CLINICAL ISOLATES

作　　者：邢志广[1] 马茹[2] 沈琪琳[1] 桂红[2] 何闻[2] 

机构地区：[1]新乡医学院第二附属医院,河南新乡453002 [2]新乡市中心医院,453002

出　　处：《中国微生态学杂志》2000年第4期224-226,共3页Chinese Journal of Microecology

摘　　要：目的　探讨病原菌种类及其对抗菌药物的耐药状况。方法　收集 1998年 1月～ 1999年 12月临床感染标本分离的病原菌并分析其种类 ,药敏试验采用 Kirby- Bauer纸片扩散法。结果　 1182株病原菌 ,革兰氏阳性球菌 6 0 4株 (5 1.1% ) ,革兰氏阴性杆菌 5 78株 (4 8.9% )。病原菌以金黄色葡萄球菌、大肠埃希菌、表皮葡萄球菌、铜绿假单胞菌最多见。去甲万古霉素、阿米卡星、新霉素对革兰氏阳性球菌抗菌作用较强 ;多粘菌素 B、头孢他啶、阿米卡星对革兰氏阴性杆菌作用较强 ;其它抗菌药物对临床病原菌呈现不同程度的耐药。结论　病原菌种类在发生变迁 ,耐药性严重 ,临床应重视病原学检查 ,开展细菌耐药性监测 。Objective To investigate the kinds of clinical isolates and their drug resistance to antimicrobial agents.Methods We collected the isolates from infectious samples in 1998 and 1999 and analysed the bacteria kinds.Bacterial susceptivity test was carried out by using Kirby Bauer method.Results Total of 1182 clinical isolates,including 604 strains (51.1%)of Gram positive cocci and 578 strains (48.9%) of Gram nagative bacilli were tested against 18 antimicrobial agents.S.aureus,E.Coli,S.epidermidis and P.aesuginosa were main microorganisms. Norvancomycin,amikacin and neomycin were the most active agents against Gram positive cocci.PolymyxinB,cetazidime and amikacin were the most active agents against Gram negative organisms.The others were drug fast against clinical isolates in different degrees. Conclusion The kinds of clinical bacteria is changing,their drug resistance to antimicrobial agents is serious.It is suggested that there is urgent need for surveillance of bacterial resistance and rational use of antimicrobial agents should be emphasised during clinical therapy.

关 键 词：病原菌 抗菌药物 耐药性 

分 类 号：R378[医药卫生—病原生物学]