HCV慢性感染者抗F蛋白抗体影响因素研究  

Study of influencing factors of serum anti-F antibody in HCV chronic infected patients

作　　者：张军[1] 丁伟良[1] 周玉麟[1] 王佳佳[2] 唐筛娣[2] 王洁[2] 邓小昭[2,3] 张云[2,3] 

机构地区：[1]宜兴市人民医院感染科,江苏宜兴214210 [2]南京医科大学公共卫生学院流行病与卫生统计学系,江苏南京210029 [3]南京军区军事医学研究所流行病与微生物研究所,江苏南京210002

出　　处：《中华疾病控制杂志》2013年第4期306-309,共4页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(81072343)

摘　　要：目的探讨丙型肝炎病毒(hepatitis C virus,HCV)慢性感染者抗F蛋白抗体阳性率的影响因素。方法收集215例抗HCV抗体阳性患者的血清标本,用间接酶联免疫吸附法(enzyme-linked immuno sorbent assay,ELISA)检测血清抗F蛋白抗体,并进行HCV RNA检测和基因分型。结果抗F蛋白抗体阳性率为66.0%(142/215);单因素分析结果显示,年龄20～岁和51～岁间抗F抗体阳性率差异有统计学意义(P<0.001)、是否合并肝硬化的F抗体阳性率差异有统计学意义(P=0.020),而性别、HCV 1b和2型、HCV RNA阳性和阴性抗F抗体阳性率间差异均无统计学意义(均有P>0.05);将年龄和肝硬化纳入Logistic回归模型得出,年龄为51～岁以及合并肝硬化会增加血清抗F蛋白抗体阳性的可能性,OR(95%CI)值分别为3.45(1.56～7.62)和1.35(1.05～1.73)。结论年龄增长、合并肝硬化会增加血清抗F蛋白抗体阳性的可能性,性别、HCV分型及HCV RNA则不会影响。Objective To investigate the distribution and influencing factors of serum anti-F in patients with chro- nic hepatitis C virus （HCV） infection. Methods Serum samples of 215 HCV chronic infected patients were recruited. In- direct enzyme-linked immuno sorbent assay （ELISA） were employed to detect serum anti-F protein antibody. HCV RNA and genotyping were detected respectively. Results There were significant correlations among anti-F antibody, age and patients with cirrhosis, but not sex, HCV RNA or types of HCV RNA. Logistic regression analysis showed that the positive rate of anti-F was higher in patients over 50 years old（ OR = 3.45,95% CI： 1.56-7.62）, and in patients with cirrhosis （ OR = 1.35,95% CI： 1.05-1.73 ）. Conclusions The results indicate that age and cirrhosis play roles in the anti-F anti- body in patients with chronic HCV infection.

关 键 词：肝炎抗体 丙型 危险因素 流行病学方法 

分 类 号：R512.63[医药卫生—内科学]