氯胺酮对单足致炎大鼠脊髓背角神经元活动的影响(英文)  

Effects of ketamine on neuronal activity of the spinal dorsal horn in rats with unilateral hindpaw inflammation

作　　者：郭华[1] 李菁锦[1] 吕国蔚[1] 

机构地区：[1]首都医科大学神经生物学系,北京100054

出　　处：《生理学报》2000年第4期351-353,共3页Acta Physiologica Sinica

基　　金：SupportedbytheNationalNaturalScienceFoundationofChina (No 396 70 871)andBeijingNaturalSciencesFoundation (796 2 0 0 9)

摘　　要：在大鼠脊髓背角用细胞外记录技术共记录到 32个单位。角叉菜胶一侧足底注射致炎后 ,电刺激该侧足底内外侧神经激动其中A、C纤维时 ,脊髓背角神经元的诱发放电数均显著增加 ;静脉注射NMDA受体拮抗剂氯胺酮后 ,A、C纤维刺激诱发的放电反应均显著下降甚至消失。致炎后脊髓背角深层单位出现Windup现象 ,静脉注射氯胺酮后该现象减轻或消失。结果提示 :角叉菜胶致炎导致脊髓背角神经元兴奋性升高和Windup ;NMDA受体参与炎症痛和Windup形成。WT5”BZ] A total of 32 units were extracellularly recorded from the spinal dorsal horn of rats. Unitary discharges evoked by stimulation of A and C fiber in ipsilateral lateral and medial plantar nerve were increased after carrageenan injection to the plantar area. The evoked responses to both A and C fiber were significantly decreased or even disappeared after administration of ketamine. The windup phenomenon was observed in neurons located deeply in the dorsal horn following carrageenan injection and was significantly suppressed or abolished after ketamine administration. The results above show NMDA receptor appears to be involved in the increase of excitability and the development of windup phenomenon in the spinal cord dorsal horn associated with carrageenan induced inflammation.

关 键 词：炎症痛 氯胺酮 脊髓背角神经元 

分 类 号：R338[医药卫生—人体生理学]